Entity Details

Primary name H14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10412
EntryNameH14_HUMAN
FullNameHistone H1.4
TaxID9606
Evidenceevidence at protein level
Length219
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesH1-4

GO terms

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GOName
GO:0000786 nucleosome
GO:0000792 heterochromatin
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0006334 nucleosome assembly
GO:0016208 AMP binding
GO:0016584 nucleosome positioning
GO:0030261 chromosome condensation
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0031936 negative regulation of chromatin silencing
GO:0032564 dATP binding
GO:0043531 ADP binding
GO:0045910 negative regulation of DNA recombination

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR005818 Linker histone H1/H5, domain H15DomainDomain
IPR005819 Linker histone H1/H5FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617537 OMIMRahman syndrome (RMNS)An autosomal dominant syndrome characterized by intellectual disability and overgrowth manifesting as increased birth length, height, weight, and/or head circumference. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule