Entity Details

Primary name PTPRF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10586
EntryNamePTPRF_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase F
TaxID9606
Evidenceevidence at protein level
Length1907
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRF

GO terms

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GOName
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0008201 heparin binding
GO:0016477 cell migration
GO:0031102 neuron projection regeneration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035373 chondroitin sulfate proteoglycan binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0044877 protein-containing complex binding
GO:0048679 regulation of axon regeneration
GO:0050839 cell adhesion molecule binding
GO:0070062 extracellular exosome
GO:0099560 synaptic membrane adhesion
GO:1900121 negative regulation of receptor binding

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616001 OMIMAplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2)A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia). The disease is caused by variants affecting the gene represented in this entry.

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
PTPRF_HUMANZ512B_HUMANBioGRID, MINT15231748 details
PTPRF_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
PTPRF_HUMANPR40A_HUMANBioGRID, HPRD, MINT15231748 details
PTPRF_HUMANPTPRF_HUMANHPRD, MINT10777529 15978577 details
PTPRF_HUMANEGFR_HUMANBioGRID, IntAct24189400 24797263 31980649 details
PTPRF_HUMANFYN_HUMANBioGRID, HPRD, IntAct12496362 31413325 details
PTPRF_HUMANCTNB1_HUMANBioGRID, HPRD11245482 12095414 9245795 details
PTPRF_HUMANLIPA1_HUMANBioGRID, HPRD27880917 7796809 8524829 9624153 details
PTPRF_HUMANRET_HUMANBioGRID11121408 details
PTPRF_HUMANNID1_HUMANBioGRID9647658 details
PTPRF_HUMANPLAK_HUMANBioGRID, HPRD9245795 details
PTPRF_HUMANLIPA3_HUMANBioGRID, HPRD9624153 details
PTPRF_HUMANLIPA2_HUMANBioGRID, HPRD9624153 details
PTPRF_HUMANLCK_HUMANBioGRID, HPRD12496362 details
PTPRF_HUMANDEP1B_HUMANBioGRID25458010 details
PTPRF_HUMANRHOA_HUMANBioGRID25458010 details
PTPRF_HUMANARHG2_HUMANBioGRID25458010 details
PTPRF_HUMANARHGB_HUMANBioGRID25458010 details
PTPRF_HUMANARHGC_HUMANBioGRID25458010 details
PTPRF_HUMANGDS1_HUMANBioGRID25458010 details
PTPRF_HUMANROCK2_HUMANBioGRID25458010 details
PTPRF_HUMANDIAP1_HUMANBioGRID25458010 details
PTPRF_HUMANSEPT9_HUMANBioGRID25458010 details
PTPRF_HUMANACTB_HUMANBioGRID25458010 details
PTPRF_HUMANTHIL_HUMANBioGRID25458010 details
PTPRF_HUMANATPA_HUMANBioGRID25458010 details
PTPRF_HUMANHS90A_HUMANBioGRID25458010 details
PTPRF_HUMANEF1A1_HUMANBioGRID25458010 details
PTPRF_HUMANEF1G_HUMANBioGRID25458010 details
PTPRF_HUMANCBR1_HUMANBioGRID25458010 details
PTPRF_HUMANG3P_HUMANBioGRID25458010 details
PTPRF_HUMANLDHB_HUMANBioGRID25458010 details
PTPRF_HUMANSEMG1_HUMANBioGRID25458010 details
PTPRF_HUMANSEMG2_HUMANBioGRID25458010 details
PTPRF_HUMANGRP75_HUMANBioGRID25458010 details
PTPRF_HUMANHS71A_HUMANBioGRID25458010 details
PTPRF_HUMANHS71B_HUMANBioGRID25458010 details
PTPRF_HUMANBIP_HUMANBioGRID25458010 details
PTPRF_HUMANHS71L_HUMANBioGRID25458010 details
PTPRF_HUMANLDHA_HUMANBioGRID25458010 details
PTPRF_HUMANTBA1B_HUMANBioGRID25458010 details
PTPRF_HUMANTBB4B_HUMANBioGRID25458010 details
PTPRF_HUMANHSP7C_HUMANBioGRID25458010 details
PTPRF_HUMANSWAHC_HUMANBioGRID25458010 details
PTPRF_HUMANLACTB_HUMANBioGRID25458010 details
PTPRF_HUMANCBP_HUMANBioGRID28680062 details
PTPRF_HUMANGPC4_HUMANBioGRID25624497 details
PTPRF_HUMANNCAN_HUMANBioGRID21976490 details
PTPRF_HUMANCSPG2_HUMANBioGRID21976490 details
PTPRF_HUMANPGCA_HUMANBioGRID21976490 details
PTPRF_HUMANPTPRZ_HUMANBioGRID21976490 details
PTPRF_HUMANPTPRA_HUMANHPRD10777529 details
PTPRF_HUMANCAV1_HUMANBioGRID, HPRD, MINT12176037 34079125 details
PTPRF_HUMANH4_HUMANBioGRID, IntAct30021884 details
PTPRF_HUMANGIT1_HUMANBioGRID12629171 details
PTPRF_HUMANTRIO_HUMANBioGRID, HPRD27880917 8643598 details
PTPRF_HUMANABCE1_HUMANBioGRID25659154 details
PTPRF_HUMANIL1AP_HUMANBioGRID22357843 details
PTPRF_HUMANPTPRD_HUMANBioGRID, HPRD12376545 22357843 details
PTPRF_HUMANIRS1_HUMANBioGRID, HPRD10660596 15588985 8732688 8995282 details
PTPRF_HUMANIRS2_HUMANHPRD15588985 8732688 details
PTPRF_HUMANBCAR1_HUMANHPRD10320483 10822386 15588985 details
PTPRF_HUMANFRS2_HUMANHPRD10822386 details
PTPRF_HUMANGALT1_HUMANHPRD9295285 details
PTPRF_HUMANINSR_HUMANHPRD11158333 1321126 15588985 details