Entity Details

Primary name COT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10589
EntryNameCOT1_HUMAN
FullNameCOUP transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length423
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesNR2F1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008270 zinc ion binding
GO:0010977 negative regulation of neuron projection development
GO:0030154 cell differentiation
GO:0043565 sequence-specific DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048856 anatomical structure development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615722 OMIMBosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS)An autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB06732 beta-NaphthoflavoneDrugbanksmall molecule