Entity Details

Primary name CH60_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10809
EntryNameCH60_HUMAN
FullName60 kDa heat shock protein, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length573
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHSPD1

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0002039 p53 binding
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 response to unfolded protein
GO:0008035 high-density lipoprotein particle binding
GO:0008637 apoptotic mitochondrial changes
GO:0009409 response to cold
GO:0009986 cell surface
GO:0016020 membrane
GO:0016032 viral process
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0030135 coated vesicle
GO:0030141 secretory granule
GO:0031625 ubiquitin protein ligase binding
GO:0032727 positive regulation of interferon-alpha production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032991 protein-containing complex
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034514 mitochondrial unfolded protein response
GO:0042026 protein refolding
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0043032 positive regulation of macrophage activation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045041 protein import into mitochondrial intermembrane space
GO:0046696 lipopolysaccharide receptor complex
GO:0048291 isotype switching to IgG isotypes
GO:0050821 protein stabilization
GO:0050870 positive regulation of T cell activation
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051131 chaperone-mediated protein complex assembly
GO:0051604 protein maturation
GO:0051702 biological process involved in interaction with symbiont
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001844 Chaperonin Cpn60FamilyFamily
IPR002423 Chaperonin Cpn60/TCP-1 familyFamilyFamily
IPR018370 Chaperonin Cpn60, conserved siteSiteConserved site
IPR027409 GroEL-like apical domain superfamilyFamilyHomologous superfamily
IPR027410 TCP-1-like chaperonin intermediate domain superfamilyFamilyHomologous superfamily
IPR027413 GroEL-like equatorial domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
605280 OMIMSpastic paraplegia 13, autosomal dominant (SPG13)A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. The disease is caused by variants affecting the gene represented in this entry.
612233 OMIMLeukodystrophy, hypomyelinating, 4 (HLD4)A severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurs within the first two decades of life. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule

Interactions

115 interactions

InteractorPartnerSourcesPublicationsLink
CH60_HUMANSIR3_HUMANBioGRID, IntAct19343720 21840382 28514442 29568061 details
CH60_HUMANMK06_HUMANBioGRID, IntAct20936779 details
CH60_HUMANLZTS2_HUMANBioGRID, IntAct, MINT21516116 25416956 25910212 details
CH60_HUMANBRCA1_HUMANBioGRID, IntAct21988832 details
CH60_HUMANCLC7A_HUMANBioGRID, IntAct21988832 details
CH60_HUMANHD_HUMANIntAct17500595 details
CH60_HUMANPLCG2_HUMANBioGRID, IntAct25814554 details
CH60_HUMANCAPON_HUMANBioGRID, IntAct25814554 details
CH60_HUMANRGS20_HUMANBioGRID, IntAct25416956 details
CH60_HUMANKRA59_HUMANBioGRID, IntAct25416956 details
CH60_HUMANKR108_HUMANBioGRID, IntAct25416956 details
CH60_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
CH60_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
CH60_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
CH60_HUMANSAMD3_HUMANBioGRID, IntAct25416956 31515488 details
CH60_HUMANCEP70_HUMANBioGRID, IntAct25416956 26871637 details
CH60_HUMANJUN_HUMANIntAct, MINT25609649 32814053 details
CH60_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
CH60_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
CH60_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
CH60_HUMANCH10_HUMANBioGRID, HPRD, IntAct10205158 11050098 12387818 14717702 19004824 22939629 26344197 29568061 details
CH60_HUMANALDH2_HUMANBioGRID, HPRD, IntAct12387818 29568061 details
CH60_HUMANOGT1_HUMANBioGRID, IntAct30021884 32994395 details
CH60_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
CH60_HUMANA4_HUMANBioGRID, IntAct17317785 21832049 32814053 details
CH60_HUMANCLAT_HUMANIntAct32814053 details
CH60_HUMANFGFR3_HUMANIntAct32814053 details
CH60_HUMANNMDE3_HUMANIntAct32814053 details
CH60_HUMANRASH_HUMANIntAct32814053 details
CH60_HUMANLIAT1_HUMANIntAct32814053 details
CH60_HUMANINCA1_HUMANIntAct32814053 details
CH60_HUMANEGFL8_HUMANIntAct32814053 details
CH60_HUMANESRP1_HUMANIntAct32814053 details
CH60_HUMANVPS29_HUMANIntAct32814053 details
CH60_HUMANDBF4A_HUMANIntAct32814053 details
CH60_HUMANTP53B_HUMANIntAct32814053 details
CH60_HUMANLASP1_HUMANIntAct32814053 details
CH60_HUMANEYA3_HUMANIntAct32814053 details
CH60_HUMANBOK_HUMANIntAct32814053 details
CH60_HUMANNFH_HUMANIntAct32814053 details
CH60_HUMANARP3_HUMANIntAct32814053 details
CH60_HUMANGCR_HUMANBioGRID10508170 details
CH60_HUMANDYR_HUMANBioGRID, HPRD8559246 8976559 details
CH60_HUMANLRRK2_HUMANBioGRID17584768 details
CH60_HUMANCLUS_HUMANBioGRID22012253 details
CH60_HUMANPLMN_HUMANBioGRID17206383 details
CH60_HUMANERG_HUMANBioGRID24591637 details
CH60_HUMANTMCC2_HUMANBioGRID25416956 25910212 details
CH60_HUMANKR103_HUMANBioGRID25416956 details
CH60_HUMANNT2NC_HUMANBioGRID25416956 details
CH60_HUMANTRI63_HUMANBioGRID23695782 details
CH60_HUMANPTEN_HUMANBioGRID26561776 details
CH60_HUMANMCPH1_HUMANBioGRID29150431 details
CH60_HUMANF107A_HUMANBioGRID28604741 details
CH60_HUMANPTN11_HUMANBioGRID19299420 details
CH60_HUMANSPT6H_HUMANBioGRID19299420 details
CH60_HUMANUBS3A_HUMANBioGRID31659016 details
CH60_HUMANSUMO2_HUMANBioGRID32786267 details
CH60_HUMANTLR1_HUMANHPRD16482509 details
CH60_HUMANNEMO_HUMANIntAct14743216 details
CH60_HUMAN1433Z_HUMANMINT15161933 details
CH60_HUMANSMAD2_HUMANIntAct20195357 details
CH60_HUMANTMM11_HUMANMINT21274005 details
CH60_HUMANB2L13_HUMANMINT22921587 details
CH60_HUMANCUL3_HUMANBioGRID, IntAct12684064 21145461 details
CH60_HUMANMFHA1_HUMANMINT24286120 details
CH60_HUMANHDAC1_HUMANBioGRID, IntAct11777905 26496610 details
CH60_HUMANETKMT_HUMANBioGRID, IntAct23349634 26186194 28514442 details
CH60_HUMANCH60_HUMANBioGRID, HPRD, IntAct11488911 29568061 details
CH60_HUMANGRP75_HUMANBioGRID, IntAct22939629 30021884 30107089 details
CH60_HUMANOR6J1_HUMANIntAct30021884 details
CH60_HUMANLRRC9_HUMANIntAct30021884 details
CH60_HUMANPRKN_HUMANBioGRID, UniProt24244333 25959826 31416196 32929329 details
CH60_HUMANATD3A_HUMANUniProt22664726 details
CH60_HUMANH2B2E_HUMANBioGRID, HPRD9724719 details
CH60_HUMANCAH2_HUMANBioGRID, HPRD10811634 9890926 details
CH60_HUMANBAK_HUMANBioGRID, HPRD12070120 details
CH60_HUMANBAX_HUMANBioGRID12070120 details
CH60_HUMANCASP3_HUMANBioGRID, HPRD10205158 10205159 details
CH60_HUMANSF3A2_HUMANBioGRID12234937 details
CH60_HUMANAMFR_HUMANBioGRID17681147 details
CH60_HUMANALK_HUMANBioGRID14968112 details
CH60_HUMANSRRM2_HUMANBioGRID16159877 details
CH60_HUMANCHIP_HUMANBioGRID17317785 details
CH60_HUMAN2ABG_HUMANBioGRID19156129 details
CH60_HUMANHDAC5_HUMANBioGRID21081666 details
CH60_HUMANPARD3_HUMANBioGRID18685789 details
CH60_HUMANISG15_HUMANBioGRID16009940 details
CH60_HUMANCUL1_HUMANBioGRID12684064 details
CH60_HUMANASB9_HUMANBioGRID17148442 details
CH60_HUMANRAF1_HUMANBioGRID15618521 details
CH60_HUMANC1QBP_HUMANBioGRID22904065 details
CH60_HUMANEFMT3_HUMANBioGRID23349634 details
CH60_HUMANITA4_HUMANBioGRID22623428 details
CH60_HUMANBCR_HUMANBioGRID16723087 details
CH60_HUMANABL1_HUMANBioGRID16723087 details
CH60_HUMANGAN_HUMANBioGRID26460568 details
CH60_HUMANPRDM1_HUMANBioGRID26823144 details
CH60_HUMANU2AF2_HUMANBioGRID26641092 details
CH60_HUMANRSCA1_HUMANBioGRID27555600 details
CH60_HUMANAPRIO_HUMANBioGRID28900035 details
CH60_HUMANPRIO_HUMANBioGRID, HPRD28900035 8676499 details
CH60_HUMANITA1_HUMANBioGRID12887919 details
CH60_HUMANAKTIP_HUMANBioGRID27512140 details
CH60_HUMANOPTN_HUMANBioGRID30945962 details
CH60_HUMANRAB10_HUMANBioGRID30945962 details
CH60_HUMANFBXL6_HUMANBioGRID31181401 details
CH60_HUMANSOX2_HUMANBioGRID21280222 details
CH60_HUMANDTNA_HUMANBioGRID20111909 details
CH60_HUMANRASA1_HUMANHPRD1347942 details
CH60_HUMANKAPCA_HUMANHPRD9724719 details
CH60_HUMANCASP9_HUMANHPRD11230124 details
CH60_HUMAN1433G_HUMANHPRD15324660 details
CH60_HUMANSUMO4_HUMANHPRD16236267 details
CH60_HUMANFHIT_HUMANHPRD19004824 details