Entity Details

Primary name IRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10914
EntryNameIRF1_HUMAN
FullNameInterferon regulatory factor 1
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesIRF1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0002819 regulation of adaptive immune response
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell population proliferation
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045088 regulation of innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR017431 Interferon regulatory factor-1/2FamilyFamily
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR031215 Interferon regulatory factor 1FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613659 OMIMGastric cancer (GASC)A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
IRF1_HUMANCDN1B_HUMANBioGRID, IntAct21988832 details
IRF1_HUMANSYQ_HUMANBioGRID, IntAct21988832 details
IRF1_HUMANSTAT1_HUMANBioGRID, HPRD, IntAct, NTNU10764778 16512786 17525742 19124747 8810328 details
IRF1_HUMANSUMO1_HUMANDIP17942705 details
IRF1_HUMANNF2L2_HUMANIntAct32911434 details
IRF1_HUMANIRF9_HUMANBioGRID, IntAct12799427 20211142 details
IRF1_HUMANKAT2B_HUMANBioGRID, HPRD10022868 11304541 23670564 details
IRF1_HUMANKAT2A_HUMANBioGRID10022868 details
IRF1_HUMANIRF8_HUMANBioGRID, HPRD11483597 7768900 9742224 details
IRF1_HUMANHMGA1_HUMANBioGRID, HPRD10357819 details
IRF1_HUMANEP300_HUMANBioGRID, HPRD10438822 14662860 15509808 23670564 details
IRF1_HUMANCBP_HUMANBioGRID9659924 details
IRF1_HUMANCHIP_HUMANBioGRID20947504 23134341 23729439 26330542 28362432 30042418 details
IRF1_HUMANTRAF3_HUMANBioGRID21903422 details
IRF1_HUMANKEAP1_HUMANBioGRID21903422 details
IRF1_HUMANNPM_HUMANBioGRID21245151 details
IRF1_HUMANYBOX1_HUMANBioGRID21245151 details
IRF1_HUMANTIF1B_HUMANBioGRID21245151 23134341 details
IRF1_HUMANSPI1_HUMANBioGRID11483597 9593745 details
IRF1_HUMANMDM2_HUMANBioGRID23134341 24583282 24721577 27795392 details
IRF1_HUMANSET_HUMANBioGRID23134341 details
IRF1_HUMANBIRC3_HUMANBioGRID24464131 29545793 details
IRF1_HUMANIRF2_HUMANBioGRID16982896 details
IRF1_HUMANXAF1_HUMANBioGRID30042418 details
IRF1_HUMANGSK3B_HUMANBioGRID30854564 details
IRF1_HUMANSPOP_HUMANBioGRID31776466 details
IRF1_HUMANULK2_HUMANIntAct17353931 details
IRF1_HUMANSMCA4_HUMANBioGRID, IntAct16195385 17182572 details
IRF1_HUMANIRF3_HUMANIntAct32878885 details
IRF1_HUMANSP2_HUMANBioGRID19482358 details
IRF1_HUMANHS90A_HUMANBioGRID23729439 details
IRF1_HUMANHS71A_HUMANBioGRID23729439 details
IRF1_HUMANHS71B_HUMANBioGRID23729439 details
IRF1_HUMANCBL_HUMANBioGRID21740303 details
IRF1_HUMANH31_HUMANBioGRID21740303 details
IRF1_HUMANPRDM1_HUMANBioGRID19828629 details
IRF1_HUMANTRAF6_HUMANBioGRID29545793 details
IRF1_HUMANFBXW7_HUMANBioGRID30854564 details
IRF1_HUMANUBE3A_HUMANBioGRID30690483 details
IRF1_HUMANNFKB1_HUMANHPRD8746784 details
IRF1_HUMANTF65_HUMANHPRD8746784 details