Entity Details

Primary name SKI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12755
EntryNameSKI_HUMAN
FullNameSki oncogene
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesSKI

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001843 neural tube closure
GO:0002089 lens morphogenesis in camera-type eye
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006351 transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009948 anterior/posterior axis specification
GO:0010626 negative regulation of Schwann cell proliferation
GO:0014902 myotube differentiation
GO:0016604 nuclear body
GO:0016605 PML body
GO:0017053 transcription repressor complex
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021772 olfactory bulb development
GO:0022011 myelination in peripheral nervous system
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0035019 somatic stem cell population maintenance
GO:0042802 identical protein binding
GO:0043010 camera-type eye development
GO:0043388 positive regulation of DNA binding
GO:0043585 nose morphogenesis
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046811 histone deacetylase inhibitor activity
GO:0048147 negative regulation of fibroblast proliferation
GO:0048593 camera-type eye morphogenesis
GO:0048741 skeletal muscle fiber development
GO:0048870 cell motility
GO:0060021 roof of mouth development
GO:0060041 retina development in camera-type eye
GO:0060325 face morphogenesis
GO:0060349 bone morphogenesis
GO:0060395 SMAD protein signal transduction

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003380 SKI/SNO/DAC domainDomainDomain
IPR009061 Putative DNA-binding domain superfamilyFamilyHomologous superfamily
IPR010919 SAND-like domain superfamilyFamilyHomologous superfamily
IPR014890 c-SKI SMAD4-binding domainDomainDomain
IPR023216 Transcription regulator SKI/SnoNFamilyFamily
IPR028760 Ski oncogeneFamilyFamily
IPR037000 Ski-like, DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
182212 OMIMShprintzen-Goldberg craniosynostosis syndrome (SGS)A very rare syndrome characterized by a marfanoid habitus, craniosynostosis, characteristic dysmorphic facial features, skeletal and cardiovascular abnormalities, mental retardation, developmental delay and learning disabilities. The disease is caused by variants affecting the gene represented in this entry.

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
SKI_HUMANSMAD3_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10575014 11306568 12154125 12426322 12732634 12764135 12857746 12874272 14525983 14699069 17283070 17469184 19032343 19875456 22442258 25670202 details
SKI_HUMANSMAD4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10531062 12419246 12732634 12764135 12857746 12874272 14525983 14699069 15231748 15761153 17469184 19032343 20959473 25609649 25670202 26977879 28468752 details
SKI_HUMANNCOR1_HUMANBioGRID, HPRD, IntAct, UniProt10049357 11430826 12764135 14525983 19032343 details
SKI_HUMANSIN3A_HUMANBioGRID, HPRD, UniProt10049357 10823891 11430826 14525983 21149449 details
SKI_HUMANSMAD2_HUMANBioGRID, HPRD, IntAct10485843 10575014 12732634 12764135 12874272 14699069 17283070 18729074 19032343 20959473 21149449 22442258 25670202 26977879 28468752 details
SKI_HUMANSNW1_HUMANBioGRID, HPRD11522815 9569025 details
SKI_HUMANHIPK2_HUMANBioGRID, HPRD12874272 details
SKI_HUMANSMAD1_HUMANBioGRID12426322 12874272 14699069 details
SKI_HUMANPML_HUMANBioGRID, HPRD11430826 details
SKI_HUMANNFIX_HUMANBioGRID, HPRD9380514 details
SKI_HUMANSKI_HUMANBioGRID, HPRD10575014 25670202 9927733 details
SKI_HUMANSKIL_HUMANBioGRID, HPRD12764135 16959829 25059663 9927733 details
SKI_HUMANMECP2_HUMANBioGRID, HPRD11441023 details
SKI_HUMANGLI2_HUMANBioGRID, HPRD12435627 details
SKI_HUMANGLI3_HUMANBioGRID, HPRD12435627 details
SKI_HUMANMYB_HUMANBioGRID14761981 details
SKI_HUMANTIF1B_HUMANBioGRID14761981 details
SKI_HUMANSPI1_HUMANBioGRID17621263 details
SKI_HUMANTGFR1_HUMANBioGRID20959473 details
SKI_HUMANUBC9_HUMANBioGRID22411991 details
SKI_HUMANAKT1_HUMANBioGRID19875456 details
SKI_HUMANHDAC3_HUMANBioGRID, IntAct16987993 17621263 19032343 19341714 details
SKI_HUMANRN165_HUMANDIP23610558 details
SKI_HUMANJUN_HUMANBioGRID, HPRD12034730 details
SKI_HUMANRARA_HUMANBioGRID16424870 19341714 details
SKI_HUMANPRD16_HUMANBioGRID19049980 details
SKI_HUMANSIX1_HUMANBioGRID19008232 details
SKI_HUMANEYA3_HUMANBioGRID19008232 details
SKI_HUMANGATA1_HUMANBioGRID15542823 details
SKI_HUMANRB_HUMANBioGRID9988677 details
SKI_HUMANSMAD5_HUMANBioGRID14699069 details
SKI_HUMANSIAH2_HUMANBioGRID20691163 details
SKI_HUMANP53_HUMANBioGRID21149449 details
SKI_HUMANSIR1_HUMANBioGRID21149449 details
SKI_HUMANESR1_HUMANBioGRID22227247 details
SKI_HUMANRN111_HUMANBioGRID17510063 18451154 23530056 details
SKI_HUMANRBCC1_HUMANBioGRID21795712 details
SKI_HUMANAXIN1_HUMANBioGRID21795712 details
SKI_HUMANAKT2_HUMANBioGRID19875456 details
SKI_HUMANLATS2_HUMANBioGRID25670202 details
SKI_HUMANSTK38_HUMANBioGRID25670202 details
SKI_HUMANST38L_HUMANBioGRID25670202 details
SKI_HUMANMERTK_HUMANBioGRID25670202 details
SKI_HUMANSAV1_HUMANBioGRID25670202 details
SKI_HUMANMOB1A_HUMANBioGRID25670202 details
SKI_HUMANMOB1B_HUMANBioGRID25670202 details
SKI_HUMANTEAD1_HUMANBioGRID25670202 details
SKI_HUMANTEAD4_HUMANBioGRID25670202 details
SKI_HUMANSMUF2_HUMANBioGRID28468752 details
SKI_HUMANSHRPN_HUMANBioGRID29227283 details