Entity Details

Primary name ACE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12821
EntryNameACE_HUMAN
FullNameAngiotensin-converting enzyme
TaxID9606
Evidenceevidence at protein level
Length1306
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesACE

GO terms

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GOName
GO:0001822 kidney development
GO:0001974 blood vessel remodeling
GO:0002003 angiotensin maturation
GO:0002019 regulation of renal output by angiotensin
GO:0002446 neutrophil mediated immunity
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0003779 actin binding
GO:0004175 endopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0008217 regulation of blood pressure
GO:0008237 metallopeptidase activity
GO:0008238 exopeptidase activity
GO:0008240 tripeptidyl-peptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0008270 zinc ion binding
GO:0009897 external side of plasma membrane
GO:0010608 posttranscriptional regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014910 regulation of smooth muscle cell migration
GO:0016021 integral component of membrane
GO:0019229 regulation of vasoconstriction
GO:0031404 chloride ion binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031711 bradykinin receptor binding
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032943 mononuclear cell proliferation
GO:0042447 hormone catabolic process
GO:0043171 peptide catabolic process
GO:0050435 amyloid-beta metabolic process
GO:0050482 arachidonic acid secretion
GO:0051019 mitogen-activated protein kinase binding
GO:0060047 heart contraction
GO:0060177 regulation of angiotensin metabolic process
GO:0060218 hematopoietic stem cell differentiation
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070573 metallodipeptidase activity
GO:0071838 cell proliferation in bone marrow
GO:0097746 blood vessel diameter maintenance
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1902033 regulation of hematopoietic stem cell proliferation
GO:1903597 negative regulation of gap junction assembly
GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001548 Peptidase M2, peptidyl-dipeptidase AFamilyFamily

Diseases

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Disease IDSourceNameDescription
267430 OMIMRenal tubular dysgenesis (RTD)Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). The disease is caused by variants affecting the gene represented in this entry.
601367 OMIMIschemic stroke (ISCHSTR)A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variants affecting the gene represented in this entry.
612624 OMIMMicrovascular complications of diabetes 3 (MVCD3)Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Disease susceptibility is associated with variants affecting the gene represented in this entry.
614519 OMIMIntracerebral hemorrhage (ICH)A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00178 RamiprilDrugbanksmall molecule
DB00492 FosinoprilDrugbanksmall molecule
DB00519 TrandolaprilDrugbanksmall molecule
DB00542 BenazeprilDrugbanksmall molecule
DB00584 EnalaprilDrugbanksmall molecule
DB00616 CandoxatrilDrugbanksmall molecule
DB00691 MoexiprilDrugbanksmall molecule
DB00722 LisinoprilDrugbanksmall molecule
DB00790 PerindoprilDrugbanksmall molecule
DB00881 QuinaprilDrugbanksmall molecule
DB00886 OmapatrilatDrugbanksmall molecule
DB01180 RescinnamineDrugbanksmall molecule
DB01197 CaptoprilDrugbanksmall molecule
DB01340 CilazaprilDrugbanksmall molecule
DB01348 SpiraprilDrugbanksmall molecule
DB02032 EpicaptoprilDrugbanksmall molecule
DB03740 N-acetyl-alpha-D-glucosamineDrugbanksmall molecule
DB08836 TemocaprilDrugbanksmall molecule
DB09477 EnalaprilatDrugbanksmall molecule
DB13166 ZofenoprilDrugbanksmall molecule
DB15565 CilazaprilatDrugbanksmall molecule