Entity Details

Primary name HEM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13196
EntryNameHEM1_HUMAN
FullName5-aminolevulinate synthase, nonspecific, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length640
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesALAS1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0003870 5-aminolevulinate synthase activity
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0007005 mitochondrion organization
GO:0019222 regulation of metabolic process
GO:0030170 pyridoxal phosphate binding
GO:0042541 hemoglobin biosynthetic process
GO:0042802 identical protein binding
GO:0048821 erythrocyte development

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding siteSiteBinding site
IPR004839 Aminotransferase, class I/classIIDomainDomain
IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthaseDomainDomain
IPR015118 5-aminolevulinate synthase presequenceDomainDomain
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule

Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
HEM1_HUMANEP400_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
HEM1_HUMANPDIP2_HUMANBioGRID, IntAct, MINT21516116 25416956 details
HEM1_HUMANDUS19_HUMANBioGRID, IntAct, MINT21516116 25416956 26186194 28514442 32296183 details
HEM1_HUMANUROK_HUMANBioGRID, IntAct21988832 details
HEM1_HUMANCH033_HUMANBioGRID, MINT21900206 details
HEM1_HUMANCDK5_HUMANBioGRID, MINT21900206 details
HEM1_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
HEM1_HUMANNUDT3_HUMANBioGRID, MINT21900206 details
HEM1_HUMANPK3CB_HUMANBioGRID, MINT21900206 details
HEM1_HUMANRAP1B_HUMANBioGRID, MINT21900206 details
HEM1_HUMANSUMO2_HUMANBioGRID, MINT21900206 details
HEM1_HUMANKITH_HUMANBioGRID, MINT21900206 details
HEM1_HUMANWIPF1_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANPEPL_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANTYB10_HUMANBioGRID, IntAct21516116 25416956 32296183 details
HEM1_HUMANTCEA2_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANRTL8B_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANLONF1_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANBCL7A_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANTTC23_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANCDC73_HUMANBioGRID, IntAct25416956 25910212 31515488 details
HEM1_HUMANMTFR2_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANKLH35_HUMANBioGRID, IntAct25416956 32814053 details
HEM1_HUMANSNX20_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANZN564_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANCERK1_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANCCHCR_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANTEKT4_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANZFY26_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANSH24A_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANGNL3L_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANCB042_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANUBP20_HUMANBioGRID, IntAct25416956 details
HEM1_HUMANZN175_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANHEM1_HUMANBioGRID, IntAct25416956 32296183 details
HEM1_HUMANSTABP_HUMANBioGRID, HPRD, IntAct16730941 details
HEM1_HUMANHSBPL_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANKIF9_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANRU2B_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANCAP2_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANLRC45_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANGRCR1_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANJERKY_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANCOBL_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANFBXL8_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANRN168_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANMTSS2_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANUT14C_HUMANBioGRID, IntAct32296183 details
HEM1_HUMANOXYR_HUMANBioGRID, MINT28298427 details
HEM1_HUMANICAM5_HUMANIntAct32814053 details
HEM1_HUMANIDLC_HUMANIntAct32814053 details
HEM1_HUMANTYB4_HUMANBioGRID25416956 details
HEM1_HUMANZMAT1_HUMANBioGRID25416956 32296183 details
HEM1_HUMANPIBF1_HUMANBioGRID32296183 details
HEM1_HUMANFXR1_HUMANMINT21653829 details
HEM1_HUMANVHL_HUMANBioGRID16234850 details