Entity Details

Primary name HLAE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13747
EntryNameHLAE_HUMAN
FullNameHLA class I histocompatibility antigen, alpha chain E
TaxID9606
Evidenceevidence at protein level
Length358
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesHLA-E

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001815 positive regulation of antibody-dependent cellular cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002519 natural killer cell tolerance induction
GO:0002639 positive regulation of immunoglobulin production
GO:0002715 regulation of natural killer cell mediated immunity
GO:0002717 positive regulation of natural killer cell mediated immunity
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016032 viral process
GO:0019731 antibacterial humoral response
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032398 MHC class Ib protein complex
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032759 positive regulation of TRAIL production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042612 MHC class I protein complex
GO:0045087 innate immune response
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Golgi apparatus membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table