Entity Details

Primary name HGF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14210
EntryNameHGF_HUMAN
FullNameHepatocyte growth factor
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesHGF

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0000902 cell morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0008083 growth factor activity
GO:0010507 negative regulation of autophagy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030212 hyaluronan metabolic process
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0031100 animal organ regeneration
GO:0031643 positive regulation of myelination
GO:0032715 negative regulation of interleukin-6 production
GO:0032733 positive regulation of interleukin-10 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044877 protein-containing complex binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050673 epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051450 myoblast proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572 positive regulation of neuron projection regeneration
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1900744 regulation of p38MAPK cascade
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902947 regulation of tau-protein kinase activity
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003609 PAN/Apple domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR024174 Hepatocyte growth factor/Macrophage stimulatory proteinFamilyFamily
IPR027284 Hepatocyte growth factorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608265 OMIMDeafness, autosomal recessive, 39 (DFNB39)A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB02264 O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB03959 N,O6-Disulfo-GlucosamineDrugbanksmall molecule
DB05434 ABT-510Drugbanksmall molecule
DB12307 ForetinibDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
HGF_HUMANMET_HUMANBioGRID, DIP, HPRD, IntAct15167892 16537482 1655405 17804794 17981115 1846706 18495663 18593464 19433454 20624990 22897854 28205554 8380735 details
HGF_HUMANHGF_HUMANBioGRID, DIP, HPRD, IntAct11597998 12051906 17804794 20624990 22897854 9817840 9886295 details
HGF_HUMANSRPX2_HUMANIntAct22242148 details
HGF_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
HGF_HUMANATL4_HUMANBioGRID, IntAct25416956 details
HGF_HUMANHGFA_HUMANDIP, HPRD20004165 8631970 details
HGF_HUMANTETN_HUMANBioGRID, HPRD12694198 details
HGF_HUMANSDC2_HUMANBioGRID, HPRD8157651 details
HGF_HUMANSDC1_HUMANBioGRID, HPRD11830493 details
HGF_HUMANBRCA1_HUMANBioGRID25184681 details
HGF_HUMANEPHA2_HUMANBioGRID28205554 details
HGF_HUMANLATS2_HUMANBioGRID28205554 details
HGF_HUMANMYC_HUMANBioGRID28205554 details
HGF_HUMANSTK11_HUMANBioGRID28205554 details
HGF_HUMANMP2K5_HUMANBioGRID28205554 details
HGF_HUMANARNT_HUMANBioGRID28205554 details
HGF_HUMANCCND2_HUMANBioGRID28205554 details
HGF_HUMANCDK4_HUMANBioGRID28205554 details
HGF_HUMANCDK6_HUMANBioGRID28205554 details
HGF_HUMANCDN2A_HUMANBioGRID28205554 details
HGF_HUMANARF_HUMANBioGRID28205554 details
HGF_HUMANCDN2B_HUMANBioGRID28205554 details
HGF_HUMANERBB2_HUMANBioGRID28205554 details
HGF_HUMANFGFR4_HUMANBioGRID28205554 details
HGF_HUMANGLIS2_HUMANBioGRID28205554 details
HGF_HUMANMDM4_HUMANBioGRID28205554 details
HGF_HUMANMERL_HUMANBioGRID28205554 details
HGF_HUMANPGFRA_HUMANBioGRID28205554 details
HGF_HUMANRAF1_HUMANBioGRID28205554 details
HGF_HUMANTEAD2_HUMANBioGRID28205554 details
HGF_HUMANMP2K6_HUMANBioGRID28205554 details
HGF_HUMAN1433G_HUMANBioGRID28205554 details
HGF_HUMANFINC_HUMANBioGRID, HPRD, IntAct15717924 25241761 details
HGF_HUMANHEPS_HUMANHPRD15792801 details
HGF_HUMANUROK_HUMANHPRD1334458 details
HGF_HUMANVTNC_HUMANHPRD15717924 details
HGF_HUMANNGAL_HUMANHPRD15637066 details
HGF_HUMANKLKB1_HUMANHPRD10962009 12372819 details
HGF_HUMANST14_HUMANHPRD10962009 12372819 details
HGF_HUMANFA11_HUMANHPRD10962009 12372819 details