Entity Details

Primary name IDE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14735
EntryNameIDE_HUMAN
FullNameInsulin-degrading enzyme
TaxID9606
Evidenceevidence at protein level
Length1019
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesIDE

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001618 virus receptor activity
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0008104 protein localization
GO:0008270 zinc ion binding
GO:0008286 insulin receptor signaling pathway
GO:0008340 determination of adult lifespan
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010815 bradykinin catabolic process
GO:0010992 ubiquitin recycling
GO:0016323 basolateral plasma membrane
GO:0016887 ATP hydrolysis activity
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0030163 protein catabolic process
GO:0031597 cytosolic proteasome complex
GO:0031626 beta-endorphin binding
GO:0032092 positive regulation of protein binding
GO:0042277 peptide binding
GO:0042447 hormone catabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043171 peptide catabolic process
GO:0043559 insulin binding
GO:0044257 cellular protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045732 positive regulation of protein catabolic process
GO:0045861 negative regulation of proteolysis
GO:0050435 amyloid-beta metabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0070062 extracellular exosome
GO:0097242 amyloid-beta clearance
GO:0140036 ubiquitin-dependent protein binding
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1901142 insulin metabolic process
GO:1901143 insulin catabolic process
GO:1903715 regulation of aerobic respiration

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001431 Peptidase M16, zinc-binding siteSiteBinding site
IPR007863 Peptidase M16, C-terminalDomainDomain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-likeFamilyHomologous superfamily
IPR011765 Peptidase M16, N-terminalDomainDomain
IPR032632 Peptidase M16, middle/third domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB00626 BacitracinDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule