Entity Details

Primary name I23O1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14902
EntryNameI23O1_HUMAN
FullNameIndoleamine 2,3-dioxygenase 1
TaxID9606
Evidenceevidence at protein level
Length403
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesIDO1

GO terms

Show/Hide Table
GOName
GO:0002376 immune system process
GO:0002666 positive regulation of T cell tolerance induction
GO:0002678 positive regulation of chronic inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006569 tryptophan catabolic process
GO:0006954 inflammatory response
GO:0007565 female pregnancy
GO:0009055 electron transfer activity
GO:0019441 tryptophan catabolic process to kynurenine
GO:0020037 heme binding
GO:0030485 smooth muscle contractile fiber
GO:0032421 stereocilium bundle
GO:0032496 response to lipopolysaccharide
GO:0032693 negative regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0033555 multicellular organismal response to stress
GO:0033754 indoleamine 2,3-dioxygenase activity
GO:0034276 kynurenic acid biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0036269 swimming behavior
GO:0042130 negative regulation of T cell proliferation
GO:0046872 metal ion binding
GO:0070233 negative regulation of T cell apoptotic process
GO:0070234 positive regulation of T cell apoptotic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000898 Indoleamine 2,3-dioxygenaseFamilyFamily
IPR037217 Tryptophan/Indoleamine 2,3-dioxygenase-likeFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00150 TryptophanDrugbanksmall molecule
DB00435 Nitric OxideDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

5 interactions