Entity Details

Primary name PLAK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14923
EntryNamePLAK_HUMAN
FullNameJunction plakoglobin
TaxID9606
Evidenceevidence at protein level
Length745
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesJUP

GO terms

Show/Hide Table
GOName
GO:0001533 cornified envelope
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002159 desmosome assembly
GO:0003713 transcription coactivator activity
GO:0005198 structural molecule activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005915 zonula adherens
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030018 Z disc
GO:0030057 desmosome
GO:0031424 keratinization
GO:0032993 protein-DNA complex
GO:0034332 adherens junction organization
GO:0035580 specific granule lumen
GO:0042127 regulation of cell population proliferation
GO:0042307 positive regulation of protein import into nucleus
GO:0042803 protein homodimerization activity
GO:0043312 neutrophil degranulation
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0044877 protein-containing complex binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050839 cell adhesion molecule binding
GO:0050982 detection of mechanical stimulus
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0071603 endothelial cell-cell adhesion
GO:0071665 gamma-catenin-TCF7L2 complex
GO:0071681 cellular response to indole-3-methanol
GO:0072659 protein localization to plasma membrane
GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098609 cell-cell adhesion
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0106006 cytoskeletal protein-membrane anchor activity
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cytoplasm
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR013284 Beta-cateninFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR030461 Junction plakoglobinFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
601214 OMIMNaxos disease (NXD)An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia. The disease is caused by variants affecting the gene represented in this entry.
611528 OMIMArrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12)A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule

Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
PLAK_HUMANZFYV9_HUMANBioGRID, HPRD, MINT15231748 details
PLAK_HUMANGDIR1_HUMANBioGRID, HPRD, IntAct16169070 details
PLAK_HUMANBIRC2_HUMANBioGRID, HPRD, IntAct16189514 details
PLAK_HUMANNTAQ1_HUMANBioGRID, HPRD, IntAct16189514 19060904 details
PLAK_HUMANRIBC2_HUMANBioGRID, HPRD, IntAct16189514 details
PLAK_HUMANCNBP1_HUMANBioGRID, HPRD, IntAct16189514 17353931 32296183 details
PLAK_HUMANDESP_HUMANBioGRID, HPRD, IntAct17353931 24981860 25225338 9348293 9739078 details
PLAK_HUMANAPC_HUMANBioGRID, HPRD, IntAct11136974 11348595 11707392 20936779 25241761 26496610 7651399 8074697 9298899 details
PLAK_HUMANCTNA1_HUMANBioGRID, HPRD, IntAct14517306 20936779 22939629 25241761 26344197 34079125 7650039 7890674 9110993 9762469 details
PLAK_HUMANNFAC4_HUMANBioGRID, IntAct21988832 details
PLAK_HUMANBRCA1_HUMANBioGRID, IntAct21988832 details
PLAK_HUMANDSG2_HUMANBioGRID, HPRD, IntAct10769205 11710948 17559062 8749329 details
PLAK_HUMANCC130_HUMANBioGRID, MINT22365833 details
PLAK_HUMANERBB2_HUMANBioGRID, HPRD, IntAct25241761 7702605 details
PLAK_HUMANITF2_HUMANbhf-ucl, BioGRID, HPRD14517306 14661054 16306047 details
PLAK_HUMANEGFR_HUMANBioGRID, IntAct14517306 24658140 24797263 25402006 31980649 9535896 details
PLAK_HUMANFHL2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
PLAK_HUMANAXIN1_HUMANBioGRID, HPRD, IntAct10488109 26496610 26871637 details
PLAK_HUMANRSP14_HUMANBioGRID, IntAct32296183 details
PLAK_HUMANPRR35_HUMANBioGRID, IntAct32296183 details
PLAK_HUMANTF7L2_HUMANBioGRID, IntAct11711551 32296183 details
PLAK_HUMANCTNA3_HUMANBioGRID, IntAct23136403 23718855 32296183 details
PLAK_HUMANDDX6_HUMANBioGRID, IntAct32296183 details
PLAK_HUMANDSG1_HUMANBioGRID, DIP, HPRD12847106 19136012 24981860 7738346 9606214 details
PLAK_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
PLAK_HUMANCSRN3_HUMANIntAct17924338 details
PLAK_HUMANSRCH_HUMANIntAct17924338 details
PLAK_HUMANIKBE_HUMANBioGRID, HPRD16189514 details
PLAK_HUMANCADH1_HUMANBioGRID14517306 1639850 22375065 25468996 27684187 7542250 8074697 8207061 9535896 details
PLAK_HUMANCADH5_HUMANBioGRID, HPRD12003790 9434630 9739078 details
PLAK_HUMANPKP3_HUMANBioGRID12707304 details
PLAK_HUMANPKP2_HUMANBioGRID, HPRD11790773 details
PLAK_HUMANPTPRF_HUMANBioGRID, HPRD9245795 details
PLAK_HUMANPTPRK_HUMANBioGRID, HPRD8663237 details
PLAK_HUMANDSC1_HUMANBioGRID, HPRD14673151 24981860 7971964 9606214 details
PLAK_HUMANCAD10_HUMANBioGRID24722188 details
PLAK_HUMANPTEN_HUMANBioGRID26561776 details
PLAK_HUMANHS90A_HUMANBioGRID27684187 31273033 details
PLAK_HUMANTBP_HUMANBioGRID14517306 details
PLAK_HUMANPSN1_HUMANBioGRID, HPRD11226248 16306047 19114997 details
PLAK_HUMANSOMA_HUMANIntAct17353931 details
PLAK_HUMANCK5P3_HUMANIntAct17353931 details
PLAK_HUMANPECA1_HUMANBioGRID, HPRD, IntAct10801826 details
PLAK_HUMANPTPRJ_HUMANHPRD, MINT12370829 details
PLAK_HUMANFRMD5_HUMANMINT22846708 details
PLAK_HUMANWWTR1_HUMANIntAct23245942 details
PLAK_HUMANCTNB1_HUMANbhf-ucl, BioGRID, IntAct11712088 17510365 25241761 26496610 27684187 34079125 9535896 details
PLAK_HUMANLEF1_HUMANbhf-ucl14661054 details
PLAK_HUMANCTNA2_HUMANbhf-ucl, BioGRID26344197 7650039 details
PLAK_HUMANCADH2_HUMANbhf-ucl, BioGRID, DIP, HPRD12604612 14625392 1639850 17098867 22939629 7650039 8074697 details
PLAK_HUMANMUC1_HUMANBioGRID, HPRD12939402 9139698 details
PLAK_HUMANCADH3_HUMANBioGRID10910767 details
PLAK_HUMANPTN14_HUMANBioGRID, HPRD12808048 details
PLAK_HUMANRAB8B_HUMANBioGRID12639940 details
PLAK_HUMANDSG3_HUMANBioGRID, HPRD7738346 details
PLAK_HUMANFBW1A_HUMANBioGRID, HPRD10803460 25900982 details
PLAK_HUMANDSC2_HUMANBioGRID, HPRD9443898 details
PLAK_HUMANCXB1_HUMANBioGRID7971964 details
PLAK_HUMANDSC3_HUMANBioGRID, HPRD10769211 details
PLAK_HUMANABCE1_HUMANBioGRID25659154 details
PLAK_HUMANCBP_HUMANBioGRID26657156 details
PLAK_HUMANEP300_HUMANBioGRID26657156 details
PLAK_HUMANCTND1_HUMANBioGRID, HPRD27684187 7876318 details
PLAK_HUMANFBXW7_HUMANBioGRID29408378 details
PLAK_HUMANPKD1_HUMANHPRD11274246 details
PLAK_HUMANCAD15_HUMANHPRD9168809 details
PLAK_HUMANSRC_HUMANHPRD14517306 details
PLAK_HUMANFER_HUMANHPRD14517306 details
PLAK_HUMANFYN_HUMANHPRD14517306 details