Entity Details

Primary name FOLR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15328
EntryNameFOLR1_HUMAN
FullNameFolate receptor alpha
TaxID9606
Evidenceevidence at protein level
Length257
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesFOLR1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001947 heart looping
GO:0003147 neural crest cell migration involved in heart formation
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0005542 folic acid binding
GO:0005634 nucleus
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0007155 cell adhesion
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0015884 folic acid transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030133 transport vesicle
GO:0030136 clathrin-coated vesicle
GO:0031103 axon regeneration
GO:0031362 anchored component of external side of plasma membrane
GO:0031526 brush border membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0035036 sperm-egg recognition
GO:0038023 signaling receptor activity
GO:0046655 folic acid metabolic process
GO:0048208 COPII vesicle coating
GO:0051870 methotrexate binding
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061626 pharyngeal arch artery morphogenesis
GO:0061713 anterior neural tube closure
GO:0061714 folic acid receptor activity
GO:0070062 extracellular exosome
GO:0071231 cellular response to folic acid
GO:1904447 folate import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cytoplasmic vesicle
Endosome
Secreted

Domains

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DomainNameCategoryType
IPR004269 Folate receptorFamilyFamily
IPR018143 Folate receptor-likeDomainDomain
IPR032935 Folate receptor alphaFamilyFamily

Diseases

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Disease IDSourceNameDescription
613068 OMIMNeurodegeneration due to cerebral folate transport deficiency (NCFTD)An autosomal recessive neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00158 Folic acidDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB05168 VintafolideDrugbanksmall molecule
DB05595 FarletuzumabDrugbankbiotech

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
FOLR1_HUMANCUL3_HUMANBioGRID, IntAct21988832 details
FOLR1_HUMANIRAK3_HUMANBioGRID, IntAct21988832 details
FOLR1_HUMANCNDH2_HUMANBioGRID, IntAct21988832 details
FOLR1_HUMANS35F6_HUMANBioGRID, IntAct32296183 details
FOLR1_HUMANLT4R2_HUMANBioGRID, MINT28298427 details