Entity Details

Primary name GATA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15976
EntryNameGATA1_HUMAN
FullNameErythroid transcription factor
TaxID9606
Evidenceevidence at protein level
Length413
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesGATA1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0010725 regulation of primitive erythrocyte differentiation
GO:0017053 transcription repressor complex
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030221 basophil differentiation
GO:0030222 eosinophil differentiation
GO:0030502 negative regulation of bone mineralization
GO:0031490 chromatin DNA binding
GO:0032993 protein-DNA complex
GO:0033690 positive regulation of osteoblast proliferation
GO:0035162 embryonic hemopoiesis
GO:0035854 eosinophil fate commitment
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048821 erythrocyte development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070527 platelet aggregation
GO:0070742 C2H2 zinc finger domain binding
GO:0097028 dendritic cell differentiation
GO:0097067 cellular response to thyroid hormone stimulus
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000679 Zinc finger, GATA-typeDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR029524 Transcription factor GATA-1FamilyFamily
IPR039355 Transcription factor GATAFamilyFamily

Diseases

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Disease IDSourceNameDescription
314050 OMIMThrombocytopenia with beta-thalassemia, X-linked (XLTT)An unusual form of thrombocytopenia associated with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor. The disease is caused by variants affecting the gene represented in this entry.
300367 OMIMX-linked dyserythropoietic anemia and thrombocytopenia (XDAT)Disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes. The disease is caused by variants affecting the gene represented in this entry.
300835 OMIMAnemia without thrombocytopenia, X-linked (XLAWT)A form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals. The disease is caused by variants affecting the gene represented in this entry.

Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
GATA1_HUMANAAPK1_HUMANBioGRID, IntAct21988832 details
GATA1_HUMANCASP3_HUMANBioGRID, DIP, HPRD17167422 details
GATA1_HUMANMK06_HUMANBioGRID, MINT21900206 details
GATA1_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
GATA1_HUMANTNS2_HUMANBioGRID, IntAct25814554 27107012 details
GATA1_HUMANRIN3_HUMANBioGRID, IntAct25814554 details
GATA1_HUMANFRS3_HUMANBioGRID, IntAct25416956 32296183 details
GATA1_HUMANAAKB2_HUMANBioGRID, IntAct24722188 25416956 27107012 32296183 details
GATA1_HUMANHXA1_HUMANBioGRID, IntAct25416956 32296183 details
GATA1_HUMANKR105_HUMANIntAct25416956 details
GATA1_HUMANCCD24_HUMANBioGRID, IntAct25416956 32296183 details
GATA1_HUMANFBF1_HUMANBioGRID, IntAct25416956 details
GATA1_HUMANRADIL_HUMANBioGRID, IntAct25416956 details
GATA1_HUMANHEXI2_HUMANBioGRID, IntAct25416956 details
GATA1_HUMANKRA92_HUMANBioGRID, IntAct25416956 details
GATA1_HUMANPNMA1_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANTRAF1_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANRBPMS_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANMDFI_HUMANBioGRID, IntAct25910212 27107012 details
GATA1_HUMANFHL3_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANBCL6_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANGLRX3_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANGOGA2_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANFANCG_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANVA0D1_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANGRAP2_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANPP16B_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANPSMF1_HUMANBioGRID, IntAct27107012 details
GATA1_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANPLS4_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANPITX1_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANDGC6L_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANKRA45_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANARMC7_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANCHRD_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANKR411_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANFANCL_HUMANBioGRID, IntAct32296183 details
GATA1_HUMANTRIP6_HUMANBioGRID, IntAct25910212 26186194 28514442 details
GATA1_HUMANLZTS2_HUMANBioGRID, IntAct25910212 details
GATA1_HUMANKRA32_HUMANBioGRID, IntAct25910212 details
GATA1_HUMANMED1_HUMANBioGRID, DIP, HPRD11724781 17132730 details
GATA1_HUMANFOG1_HUMANBioGRID, DIP, HPRD11675338 19513100 9230307 details
GATA1_HUMANNF2L2_HUMANIntAct32911434 details
GATA1_HUMANCRYA2_HUMANIntAct32814053 details
GATA1_HUMANFGFR3_HUMANIntAct32814053 details
GATA1_HUMANGRN_HUMANIntAct32814053 details
GATA1_HUMANGELS_HUMANIntAct32814053 details
GATA1_HUMANHSPB1_HUMANBioGRID, IntAct20410505 32814053 details
GATA1_HUMANMETK2_HUMANIntAct32814053 details
GATA1_HUMANPRPS1_HUMANIntAct32814053 details
GATA1_HUMANKLK6_HUMANIntAct32814053 details
GATA1_HUMANWFS1_HUMANIntAct32814053 details
GATA1_HUMANBAG6_HUMANIntAct32814053 details
GATA1_HUMANKLF11_HUMANIntAct32814053 details
GATA1_HUMANKIF1B_HUMANIntAct32814053 details
GATA1_HUMANRNF11_HUMANIntAct32814053 details
GATA1_HUMANPIAS4_HUMANIntAct32814053 details
GATA1_HUMANSPRE1_HUMANIntAct32814053 details
GATA1_HUMANRAI1_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANTRI29_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANZZZ3_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANTX1B3_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANTAF7_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANTRI25_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANZBT22_HUMANBioGRID, IntAct20211142 details
GATA1_HUMANFLI1_HUMANBioGRID, HPRD10364157 12556498 12724402 details
GATA1_HUMANFOG2_HUMANBioGRID, HPRD10438528 details
GATA1_HUMANHDAC3_HUMANBioGRID14668799 details
GATA1_HUMANHDAC4_HUMANBioGRID14668799 details
GATA1_HUMANHDAC5_HUMANBioGRID, HPRD14668799 details
GATA1_HUMANARI1A_HUMANBioGRID11018012 details
GATA1_HUMANSMCA4_HUMANBioGRID11018012 details
GATA1_HUMANSMRC2_HUMANBioGRID11018012 details
GATA1_HUMANSMRC1_HUMANBioGRID11018012 details
GATA1_HUMANSMRD1_HUMANBioGRID11018012 details
GATA1_HUMANSMCE1_HUMANBioGRID11018012 details
GATA1_HUMANSNF5_HUMANBioGRID11018012 details
GATA1_HUMANCBP_HUMANBioGRID, HPRD12496368 details
GATA1_HUMANTAL1_HUMANBioGRID16407974 7568177 details
GATA1_HUMANSP1_HUMANBioGRID12239153 details
GATA1_HUMANRBTN2_HUMANBioGRID, HPRD7568177 9209374 details
GATA1_HUMANSPI1_HUMANBioGRID, HPRD10364157 12202480 details
GATA1_HUMANSRA1_HUMANBioGRID20398657 details
GATA1_HUMANSPIB_HUMANBioGRID10364157 details
GATA1_HUMANAKT1_HUMANBioGRID, HPRD16107690 details
GATA1_HUMANHEMGN_HUMANBioGRID24740910 details
GATA1_HUMANPML_HUMANBioGRID24255919 details
GATA1_HUMANDNM3L_HUMANBioGRID24952347 details
GATA1_HUMANUBP7_HUMANBioGRID30872372 details
GATA1_HUMANMGT5B_HUMANBioGRID32296183 details
GATA1_HUMANUBC_HUMANMINT16858405 details
GATA1_HUMANHS71A_HUMANDIP17167422 details
GATA1_HUMANHS71B_HUMANDIP17167422 details
GATA1_HUMANRB_HUMANDIP19513100 details
GATA1_HUMANHDAC1_HUMANBioGRID14668799 details
GATA1_HUMANZBT16_HUMANBioGRID, HPRD12242665 details
GATA1_HUMANIKZF1_HUMANBioGRID19114560 details
GATA1_HUMANNDKA_HUMANBioGRID16631833 details
GATA1_HUMANSKI_HUMANBioGRID15542823 details
GATA1_HUMANCEBPE_HUMANBioGRID, HPRD12202480 details
GATA1_HUMANHSP74_HUMANBioGRID, HPRD17167422 details
GATA1_HUMANEP300_HUMANBioGRID24255919 24740910 details
GATA1_HUMANSTAT3_HUMANHPRD15673499 details
GATA1_HUMANMK01_HUMANHPRD15967790 details
GATA1_HUMANMK03_HUMANHPRD15967790 details
GATA1_HUMANHEY1_HUMANHPRD15314183 details
GATA1_HUMANZN521_HUMANHPRD19049973 details