Entity Details

Primary name ACADS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16219
EntryNameACADS_HUMAN
FullNameShort-chain specific acyl-CoA dehydrogenase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesACADS

GO terms

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GOName
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004085 butyryl-CoA dehydrogenase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005813 centrosome
GO:0006635 fatty acid beta-oxidation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359 butyrate catabolic process
GO:0050660 flavin adenine dinucleotide binding

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR006089 Acyl-CoA dehydrogenase, conserved siteSiteConserved site
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domainDomainDomain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminalDomainDomain
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamilyFamilyHomologous superfamily
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminalDomainDomain
IPR036250 Acyl-CoA dehydrogenase-like, C-terminalFamilyHomologous superfamily
IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
201470 OMIMAcyl-CoA dehydrogenase short-chain deficiency (ACADSD)An inborn error of mitochondrial fatty acid beta-oxidation resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in adults. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB03059 Acetoacetyl-CoADrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ACADS_HUMANIRF7_HUMANBioGRID, IntAct21988832 details