Entity Details

Primary name CREB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16220
EntryNameCREB1_HUMAN
FullNameCyclic AMP-responsive element-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length327
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesCREB1

GO terms

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GOName
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005759 mitochondrial matrix
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007409 axonogenesis
GO:0007568 aging
GO:0007595 lactation
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0010033 response to organic substance
GO:0010629 negative regulation of gene expression
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0014823 response to activity
GO:0016032 viral process
GO:0019899 enzyme binding
GO:0021983 pituitary gland development
GO:0030424 axon
GO:0030544 Hsp70 protein binding
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0033363 secretory granule organization
GO:0033762 response to glucagon
GO:0034670 chemotaxis to arachidonic acid
GO:0035035 histone acetyltransferase binding
GO:0035094 response to nicotine
GO:0035497 cAMP response element binding
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0040018 positive regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046887 positive regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048145 regulation of fibroblast proliferation
GO:0050821 protein stabilization
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0060251 regulation of glial cell proliferation
GO:0060430 lung saccule development
GO:0060509 type I pneumocyte differentiation
GO:0071294 cellular response to zinc ion
GO:0071300 cellular response to retinoic acid
GO:0071398 cellular response to fatty acid
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1902065 response to L-glutamate
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990589 ATF4-CREB1 transcription factor complex
GO:1990763 arrestin family protein binding
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001630 cAMP response element binding (CREB) proteinFamilyFamily
IPR003102 Coactivator CBP, pKIDDomainDomain
IPR004827 Basic-leucine zipper domainDomainDomain
IPR029802 cAMP-responsive element-binding protein 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
612160 OMIMAngiomatoid fibrous histiocytoma (AFH)A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.

Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule

Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
CREB1_HUMANBRCA1_HUMANMINT9926942 details
CREB1_HUMANSGK1_HUMANHPRD, MINT15733869 details
CREB1_HUMANCHD3_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANVIME_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANRECQ5_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANRAB1A_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANHPS6_HUMANHPRD, IntAct16169070 details
CREB1_HUMANKS6A1_HUMANBioGRID, HPRD, IntAct11175347 12235136 16282323 21832046 8688081 9687510 9829964 details
CREB1_HUMANATR_HUMANBioGRID, IntAct16293623 details
CREB1_HUMANTSSK4_HUMANBioGRID, HPRD, IntAct15964553 21988832 details
CREB1_HUMANEP300_HUMANBioGRID, MINT10506141 11313407 12665587 17476304 21212407 21268077 22787115 26944191 7870179 details
CREB1_HUMANCBP_HUMANBioGRID, DIP, HPRD, IntAct, MINT10848610 10866654 11259575 11313407 11564156 12196545 12198160 12933667 15073328 15585582 15691881 16799563 17476304 17707401 18599546 20403362 20541704 23671189 27789289 7870179 8028671 8413673 8663317 9413984 9786917 9829964 details
CREB1_HUMANATF6A_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANTOX4_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANCHD8_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANHIPK3_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANTF2AA_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANCRTC1_HUMANBioGRID, IntAct20936779 32296183 details
CREB1_HUMANPOGZ_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANRN111_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANSRBP2_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANPIAS1_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANZMYM2_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANZHX1_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANUBC9_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANK2026_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANZN451_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANPASK_HUMANMINT21418524 details
CREB1_HUMANP53_HUMANBioGRID, IntAct10848610 16611888 21295542 25241761 details
CREB1_HUMANATF1_HUMANBioGRID, HPIDb, HPRD, MINT1655749 20102225 25609649 8384217 details
CREB1_HUMANNFIL3_HUMANBioGRID, HPIDb, IntAct, MINT20102225 25609649 28514442 details
CREB1_HUMANCREB1_HUMANBioGRID, HPIDb, MINT, UniProt20102225 23661758 25609649 details
CREB1_HUMANBACH1_HUMANHPIDb20102225 details
CREB1_HUMANCR3L3_HUMANHPIDb20102225 details
CREB1_HUMANSMCO1_HUMANBioGRID, IntAct27107012 details
CREB1_HUMANPIAS2_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANCRTC2_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANHD_HUMANBioGRID, IntAct16207717 32814053 details
CREB1_HUMANTRI22_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANZNF92_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANMTF2_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANSUZ12_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANRFX3_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANZNF35_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANZN436_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANABL1_HUMANBioGRID, HPRD7565761 details
CREB1_HUMANCEBPB_HUMANBioGRID, HPRD12773552 details
CREB1_HUMANKAT5_HUMANBioGRID, HPRD10720489 details
CREB1_HUMANKCC2A_HUMANBioGRID8663317 details
CREB1_HUMANRBBP4_HUMANBioGRID10866654 details
CREB1_HUMANKS6A5_HUMANBioGRID, HPRD11018520 11500364 11909979 16223362 9687510 9873047 details
CREB1_HUMANKS6A4_HUMANBioGRID, HPRD11175347 8688081 9687510 9792677 9829964 details
CREB1_HUMANGLI2_HUMANBioGRID, HPRD10074179 details
CREB1_HUMANFHL5_HUMANBioGRID, HPRD11046156 details
CREB1_HUMANFHL2_HUMANBioGRID11046156 details
CREB1_HUMANFHL3_HUMANBioGRID11046156 details
CREB1_HUMANKAPCA_HUMANBioGRID11500364 12805224 details
CREB1_HUMANHNF1B_HUMANBioGRID9671480 details
CREB1_HUMANGCR_HUMANBioGRID, HPRD20203101 7621901 8449898 details
CREB1_HUMANMCAF1_HUMANBioGRID20936779 details
CREB1_HUMANHDAC1_HUMANBioGRID12567184 20473547 details
CREB1_HUMANPO2F1_HUMANBioGRID12391146 details
CREB1_HUMANCCDC6_HUMANBioGRID20498639 details
CREB1_HUMANPP1A_HUMANBioGRID20498639 details
CREB1_HUMANRGS13_HUMANBioGRID20974683 details
CREB1_HUMANTYY1_HUMANBioGRID7769693 details
CREB1_HUMANGSK3B_HUMANBioGRID, HPRD12162494 14635195 details
CREB1_HUMANGSK3A_HUMANBioGRID14635195 details
CREB1_HUMANSRA1_HUMANBioGRID20398657 details
CREB1_HUMANAKT1_HUMANBioGRID, HPRD9829964 details
CREB1_HUMANDAXX_HUMANBioGRID22185778 details
CREB1_HUMANKGP1_HUMANBioGRID, HPRD11175347 8688081 9687510 9829964 details
CREB1_HUMANNR5A2_HUMANBioGRID18191017 details
CREB1_HUMANATM_HUMANBioGRID, HPRD15073328 16293623 details
CREB1_HUMANDNM3L_HUMANBioGRID24952347 details
CREB1_HUMANTHA_HUMANBioGRID, HPRD12805224 details
CREB1_HUMANZEP1_HUMANBioGRID32296183 details
CREB1_HUMANPTEN_HUMANBioGRID31217297 details
CREB1_HUMANMEIS1_HUMANBioGRID, IntAct20159610 20541704 details
CREB1_HUMANNFAC1_HUMANBioGRID, MINT25609649 27637333 details
CREB1_HUMANNFAC2_HUMANBioGRID, MINT25609649 27637333 details
CREB1_HUMANCREM_HUMANBioGRID, HPRD, MINT22531917 25609649 7809053 details
CREB1_HUMANJUN_HUMANBioGRID, MINT2138276 25609649 details
CREB1_HUMANCSEN_HUMANBioGRID, HPRD12198160 details
CREB1_HUMANH31_HUMANBioGRID12933667 19279000 details
CREB1_HUMANHDAC8_HUMANBioGRID19070599 details
CREB1_HUMANDACH1_HUMANBioGRID16980615 details
CREB1_HUMANSMCA4_HUMANBioGRID16675956 23671189 details
CREB1_HUMANSMCA5_HUMANBioGRID, HPRD16675956 details
CREB1_HUMANCARM1_HUMANBioGRID16330542 details
CREB1_HUMANMYOD1_HUMANBioGRID12665587 details
CREB1_HUMANHDAC2_HUMANBioGRID12567184 20473547 details
CREB1_HUMANTAF4_HUMANBioGRID15703171 details
CREB1_HUMANDNM3B_HUMANBioGRID19786833 details
CREB1_HUMANATX3_HUMANBioGRID11572863 details
CREB1_HUMANSIR1_HUMANBioGRID23382074 details
CREB1_HUMANYAP1_HUMANBioGRID23532963 31496812 32220262 details
CREB1_HUMANMK14_HUMANBioGRID, HPRD11377386 23532963 details
CREB1_HUMANDEAF1_HUMANBioGRID23846693 details
CREB1_HUMANNCOR1_HUMANBioGRID24315104 details
CREB1_HUMANCTNB1_HUMANBioGRID17962194 19223551 23671189 details
CREB1_HUMANTRAF3_HUMANBioGRID26755589 details
CREB1_HUMANSTAT3_HUMANBioGRID26508788 details
CREB1_HUMANRFX5_HUMANBioGRID23671189 details
CREB1_HUMANNFYB_HUMANBioGRID23671189 details
CREB1_HUMANHIF1A_HUMANBioGRID27808477 details
CREB1_HUMANDYR1A_HUMANHPRD15694837 details
CREB1_HUMANSRF_HUMANHPRD7551568 9388250 details
CREB1_HUMANT2FB_HUMANHPRD8628277 details
CREB1_HUMANKS6A3_HUMANHPRD11160957 11175347 8688081 9687510 9829964 details
CREB1_HUMANPDX1_HUMANHPRD7505393 details
CREB1_HUMANKS6A2_HUMANHPRD11175347 11698596 8688081 9687510 9829964 details
CREB1_HUMANEDF1_HUMANHPRD10567391 details
CREB1_HUMANMAPK2_HUMANHPRD8887554 details
CREB1_HUMANSOX9_HUMANHPRD19113914 details