Entity Details

Primary name LEG3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17931
EntryNameLEG3_HUMAN
FullNameGalectin-3
TaxID9606
Evidenceevidence at protein level
Length250
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesLGALS3

GO terms

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GOName
GO:0070062 extracellular exosome
GO:0005634 nucleus
GO:0071674 mononuclear cell migration
GO:0045637 regulation of myeloid cell differentiation
GO:2000521 negative regulation of immunological synapse formation
GO:0005576 extracellular region
GO:0005743 mitochondrial inner membrane
GO:0070492 oligosaccharide binding
GO:1903078 positive regulation of protein localization to plasma membrane
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042129 regulation of T cell proliferation
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0090280 positive regulation of calcium ion import
GO:0031640 killing of cells of other organism
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0001772 immunological synapse
GO:0004864 protein phosphatase inhibitor activity
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:1903614 negative regulation of protein tyrosine phosphatase activity
GO:0044216 obsolete other organism cell
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:0003723 RNA binding
GO:0030246 carbohydrate binding
GO:0030593 neutrophil chemotaxis
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050918 positive chemotaxis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0002548 monocyte chemotaxis
GO:0008380 RNA splicing
GO:0070232 regulation of T cell apoptotic process
GO:0009986 cell surface
GO:0030667 secretory granule membrane
GO:0043236 laminin binding
GO:0019863 IgE binding
GO:0042056 chemoattractant activity
GO:0031334 positive regulation of protein-containing complex assembly
GO:0006397 mRNA processing
GO:0019903 protein phosphatase binding
GO:0030855 epithelial cell differentiation
GO:0005681 spliceosomal complex
GO:0048246 macrophage chemotaxis
GO:0062023 collagen-containing extracellular matrix
GO:0071677 positive regulation of mononuclear cell migration
GO:0045806 negative regulation of endocytosis
GO:0101003 ficolin-1-rich granule membrane
GO:0048245 eosinophil chemotaxis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001079 Galectin, carbohydrate recognition domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR015534 Galectin-3FamilyFamily
IPR044156 Galectin-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01827 2,3,5,6-Tetrafluoro-4-Methoxy-BenzamideDrugbanksmall molecule
DB04465 LactoseDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
LEG3_HUMANCD6_HUMANMINT24945728 details
LEG3_HUMANCD166_HUMANBioGRID, IntAct, MINT24945728 26186194 28514442 details
LEG3_HUMANCREST_HUMANBioGRID, IntAct25416956 details
LEG3_HUMANGOGA2_HUMANBioGRID, IntAct25416956 details
LEG3_HUMANPPIG_HUMANBioGRID, IntAct25416956 details
LEG3_HUMANPRR13_HUMANBioGRID, IntAct25416956 31515488 details
LEG3_HUMANLEG3_HUMANBioGRID, IntAct25416956 31515488 details
LEG3_HUMANMMP7_HUMANIntAct20812334 details
LEG3_HUMANCRX_HUMANBioGRID, IntAct32296183 details
LEG3_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
LEG3_HUMANKI16B_HUMANBioGRID, IntAct32296183 details
LEG3_HUMANNCTR3_HUMANIntAct25315772 details
LEG3_HUMANPDC6I_HUMANDIP19706535 details
LEG3_HUMANEGLN_HUMANBioGRID, UniProt31540324 details
LEG3_HUMANUROM_HUMANIntAct32045104 details
LEG3_HUMANGEMI4_HUMANBioGRID, HPRD11522829 details
LEG3_HUMANFCG2A_HUMANBioGRID, HPRD10704522 details
LEG3_HUMANELN_HUMANBioGRID, HPRD10536372 details
LEG3_HUMANLG3BP_HUMANBioGRID, HPRD11146440 16518858 1917996 24755837 26168351 8390986 8813152 details
LEG3_HUMANC1GLC_HUMANBioGRID18695044 details
LEG3_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
LEG3_HUMANA4_HUMANBioGRID21832049 details
LEG3_HUMANBARD1_HUMANBioGRID22990118 24755837 details
LEG3_HUMANPAXI1_HUMANBioGRID22990118 details
LEG3_HUMANTRIM5_HUMANBioGRID27693506 details
LEG3_HUMANTRIM6_HUMANBioGRID27693506 details
LEG3_HUMANTRI17_HUMANBioGRID27693506 details
LEG3_HUMANMEFV_HUMANBioGRID27693506 details
LEG3_HUMANTRI22_HUMANBioGRID27693506 details
LEG3_HUMANTRI23_HUMANBioGRID27693506 details
LEG3_HUMANTRI49_HUMANBioGRID27693506 details
LEG3_HUMANMCPH1_HUMANBioGRID29150431 details
LEG3_HUMANSUFU_HUMANHPRD14611647 details
LEG3_HUMANCYHR1_HUMANHPRD10745073 details
LEG3_HUMANEGFR_HUMANBioGRID, I2D19225046 21258405 23956138 details
LEG3_HUMANMICA_HUMANMINT21712812 details
LEG3_HUMANK1549_HUMANBioGRID, IntAct24755837 26186194 28514442 details
LEG3_HUMANS12A2_HUMANBioGRID, IntAct24755837 26186194 28514442 details
LEG3_HUMANECE1_HUMANBioGRID, IntAct24755837 28514442 details
LEG3_HUMANCH3L1_HUMANIntAct29427412 details
LEG3_HUMANI13R2_HUMANIntAct29427412 details
LEG3_HUMANLEG1_HUMANBioGRID11522829 details
LEG3_HUMANGTF2I_HUMANBioGRID18662664 details
LEG3_HUMANACTS_HUMANBioGRID18662664 details
LEG3_HUMANSQSTM_HUMANBioGRID24619419 details
LEG3_HUMANRAB7A_HUMANBioGRID24619419 details
LEG3_HUMANLAMP1_HUMANBioGRID24619419 30404831 details
LEG3_HUMANMLP3A_HUMANBioGRID24619419 30404831 details
LEG3_HUMANBRCA1_HUMANBioGRID24755837 details
LEG3_HUMANAT1A1_HUMANBioGRID24755837 details
LEG3_HUMANBASI_HUMANBioGRID24755837 details
LEG3_HUMANCADM1_HUMANBioGRID24755837 details
LEG3_HUMANTCPG_HUMANBioGRID24755837 details
LEG3_HUMANITB1_HUMANBioGRID24755837 details
LEG3_HUMANLAMC1_HUMANBioGRID24755837 details
LEG3_HUMAN4F2_HUMANBioGRID24755837 details
LEG3_HUMANSAHH_HUMANBioGRID24755837 details
LEG3_HUMANCKAP4_HUMANBioGRID24755837 details
LEG3_HUMANOST48_HUMANBioGRID24755837 details
LEG3_HUMANBGAL_HUMANBioGRID24755837 details
LEG3_HUMANHS90B_HUMANBioGRID24755837 details
LEG3_HUMANIPO5_HUMANBioGRID24755837 details
LEG3_HUMANIMB1_HUMANBioGRID24755837 details
LEG3_HUMANMYL6_HUMANBioGRID24755837 details
LEG3_HUMANRL35_HUMANBioGRID24755837 details
LEG3_HUMANRS20_HUMANBioGRID24755837 details
LEG3_HUMANLAMP2_HUMANBioGRID24755837 details
LEG3_HUMANMYH10_HUMANBioGRID24755837 details
LEG3_HUMANNP1L1_HUMANBioGRID24755837 details
LEG3_HUMANVIME_HUMANBioGRID24755837 details
LEG3_HUMANATPG_HUMANBioGRID24755837 details
LEG3_HUMANHORN_HUMANBioGRID24755837 details
LEG3_HUMANMCCA_HUMANBioGRID24755837 details
LEG3_HUMANODPX_HUMANBioGRID24755837 details
LEG3_HUMANACTA_HUMANBioGRID24755837 details
LEG3_HUMANCDC5L_HUMANBioGRID24755837 details
LEG3_HUMANMCCB_HUMANBioGRID24755837 details
LEG3_HUMANML12B_HUMANBioGRID24755837 details
LEG3_HUMANPARP1_HUMANBioGRID24755837 details
LEG3_HUMANPRP19_HUMANBioGRID24755837 details
LEG3_HUMANRL7A_HUMANBioGRID24755837 details
LEG3_HUMANEAA1_HUMANBioGRID24755837 details
LEG3_HUMANAAAT_HUMANBioGRID24755837 details
LEG3_HUMANLAP2A_HUMANBioGRID24755837 details
LEG3_HUMANLAP2B_HUMANBioGRID24755837 details
LEG3_HUMANNICA_HUMANBioGRID24755837 details
LEG3_HUMANPCCA_HUMANBioGRID24755837 details
LEG3_HUMANRL12_HUMANBioGRID24755837 details
LEG3_HUMANSERPH_HUMANBioGRID24755837 details
LEG3_HUMANTRI16_HUMANBioGRID27693506 details
LEG3_HUMANSYUA_HUMANBioGRID30404831 details
LEG3_HUMANTBK1_HUMANBioGRID30404831 details
LEG3_HUMANOPTN_HUMANBioGRID30404831 details
LEG3_HUMANCSK21_HUMANHPRD10961987 8253806 details
LEG3_HUMANCSK22_HUMANHPRD10961987 8253806 details
LEG3_HUMANMMP2_HUMANHPRD7947821 details
LEG3_HUMANLMIP_HUMANHPRD11532191 details
LEG3_HUMANKC1A_HUMANHPRD10961987 8253806 details
LEG3_HUMANCUBN_HUMANHPRD11856751 details