Entity Details

Primary name BMP7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18075
EntryNameBMP7_HUMAN
FullNameBone morphogenetic protein 7
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesBMP7

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001707 mesoderm formation
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0003272 endocardial cushion formation
GO:0003344 pericardium morphogenesis
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007411 axon guidance
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0009880 embryonic pattern specification
GO:0010628 positive regulation of gene expression
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016358 dendrite development
GO:0021502 neural fold elevation formation
GO:0030326 embryonic limb morphogenesis
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0030902 hindbrain development
GO:0031982 vesicle
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032355 response to estradiol
GO:0033280 response to vitamin D
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034504 protein localization to nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0043434 response to peptide hormone
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048812 neuron projection morphogenesis
GO:0050768 negative regulation of neurogenesis
GO:0051216 cartilage development
GO:0060037 pharyngeal system development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060411 cardiac septum morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060485 mesenchyme development
GO:0060548 negative regulation of cell death
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060710 chorio-allantoic fusion
GO:0061384 heart trabecula morphogenesis
GO:0062023 collagen-containing extracellular matrix
GO:0070487 monocyte aggregation
GO:0070700 BMP receptor binding
GO:0071456 cellular response to hypoxia
GO:0071773 cellular response to BMP stimulus
GO:0072040 negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072133 metanephric mesenchyme morphogenesis
GO:0072134 nephrogenic mesenchyme morphogenesis
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0090336 positive regulation of brown fat cell differentiation
GO:1900006 positive regulation of dendrite development
GO:1900106 positive regulation of hyaluranon cable assembly
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1905069 allantois development
GO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:2000121 regulation of removal of superoxide radicals

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
BMP7_HUMANNOGG_HUMANBioGRID, HPRD, IntAct12478285 details
BMP7_HUMANMTUS2_HUMANBioGRID, IntAct, MINT21516116 25416956 31515488 details
BMP7_HUMANKHDR2_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANNT2NC_HUMANBioGRID, IntAct25416956 32296183 details
BMP7_HUMANTRI27_HUMANBioGRID, IntAct25416956 31515488 32296183 details
BMP7_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANKR108_HUMANBioGRID, IntAct25416956 32296183 details
BMP7_HUMANCC125_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANKRA98_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANKR109_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANKR123_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANBEGIN_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANKRA59_HUMANBioGRID, IntAct25416956 32296183 details
BMP7_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
BMP7_HUMANCCDB1_HUMANIntAct31515488 details
BMP7_HUMANNT2NA_HUMANBioGRID, IntAct25416956 31515488 32296183 details
BMP7_HUMANBMPR2_HUMANBioGRID, HPRD7644468 7791754 details
BMP7_HUMANBMR1A_HUMANBioGRID, HPRD18070108 7791754 8006002 8605097 details
BMP7_HUMANBMR1B_HUMANBioGRID, HPRD18070108 8006002 8605097 details
BMP7_HUMANACVR1_HUMANBioGRID, HPRD18070108 8006002 details
BMP7_HUMANAVR2A_HUMANBioGRID, HPRD12667445 18070108 9748228 details
BMP7_HUMANACTN4_HUMANBioGRID25416956 details
BMP7_HUMANKR107_HUMANBioGRID25416956 details
BMP7_HUMANKR103_HUMANBioGRID25416956 details
BMP7_HUMANTDGF1_HUMANBioGRID28126904 details
BMP7_HUMANKRA13_HUMANBioGRID32296183 details
BMP7_HUMANSOSD1_HUMANBioGRID, HPRD14623234 15020244 details
BMP7_HUMANBMP7_HUMANBioGRID12478285 details
BMP7_HUMANEGLN_HUMANBioGRID, HPRD9872992 details
BMP7_HUMANAVR2B_HUMANBioGRID, HPRD9748228 details
BMP7_HUMANSMAD3_HUMANBioGRID20093492 details
BMP7_HUMANUBE4A_HUMANBioGRID30663414 details
BMP7_HUMANNCOA3_HUMANHPRD7791754 details
BMP7_HUMANGDF7_HUMANHPRD12741987 details
BMP7_HUMANCRDL2_HUMANHPRD14660436 details