Entity Details

Primary name PTPRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18433
EntryNamePTPRA_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase alpha
TaxID9606
Evidenceevidence at protein level
Length802
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRA

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0016020 membrane
GO:0043235 receptor complex
GO:0050804 modulation of chemical synaptic transmission
GO:0051893 regulation of focal adhesion assembly
GO:0070062 extracellular exosome
GO:0098685 Schaffer collateral - CA1 synapse
GO:0099699 integral component of synaptic membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-typeFamilyFamily
IPR027262 Receptor tyrosine-protein phosphatase alphaFamilyFamily
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
PTPRA_HUMANPTPRA_HUMANBioGRID, HPRD, MINT15978577 27432908 32062451 7518772 details
PTPRA_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT11923305 19380743 23532252 24189400 27880917 28065597 28330616 28514442 31980649 32062451 7518772 8670803 details
PTPRA_HUMANSRC_HUMANBioGRID, HPRD, MINT10698938 11923305 12468645 23532252 7518772 8647855 9261115 details
PTPRA_HUMANGBRL2_HUMANBioGRID, MINT21900206 details
PTPRA_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
PTPRA_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
PTPRA_HUMANEGFR_HUMANBioGRID, IntAct, MINT28065597 31980649 32062451 details
PTPRA_HUMANSHC1_HUMANMINT28065597 details
PTPRA_HUMANKCNA2_HUMANBioGRID, HPRD15588985 9878055 details
PTPRA_HUMANMBP_HUMANBioGRID23532252 details
PTPRA_HUMANSHPS1_HUMANBioGRID19299420 details
PTPRA_HUMANRET_HUMANBioGRID32062451 details
PTPRA_HUMANPTPRM_HUMANHPRD10777529 details
PTPRA_HUMANPTPRF_HUMANHPRD10777529 details
PTPRA_HUMANPTPRD_HUMANHPRD10777529 details
PTPRA_HUMANFYN_HUMANBioGRID, HPRD8980254 9535845 details
PTPRA_HUMANCALM1_HUMANBioGRID, HPRD10893241 details
PTPRA_HUMANCALM2_HUMANBioGRID, HPRD10893241 details
PTPRA_HUMANCALM3_HUMANBioGRID, HPRD10893241 details
PTPRA_HUMANERBB2_HUMANBioGRID28065597 32062451 details
PTPRA_HUMANPTPRG_HUMANBioGRID23532252 details
PTPRA_HUMANNCHL1_HUMANBioGRID18046458 details
PTPRA_HUMANKPCD_HUMANHPRD11676480 11923305 details
PTPRA_HUMANPTPRS_HUMANHPRD10777529 details
PTPRA_HUMANBCAR1_HUMANHPRD10787408 15588985 details