Entity Details

Primary name PACA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18509
EntryNamePACA_HUMAN
FullNamePituitary adenylate cyclase-activating polypeptide
TaxID9606
Evidenceevidence at protein level
Length176
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesADCYAP1

GO terms

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GOName
GO:0001541 ovarian follicle development
GO:0001662 behavioral fear response
GO:0001821 histamine secretion
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus
GO:0005102 signaling receptor binding
GO:0005184 neuropeptide hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010976 positive regulation of neuron projection development
GO:0016521 pituitary adenylate cyclase activating polypeptide activity
GO:0019233 sensory perception of pain
GO:0019933 cAMP-mediated signaling
GO:0021983 pituitary gland development
GO:0030073 insulin secretion
GO:0031175 neuron projection development
GO:0031858 pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0032755 positive regulation of interleukin-6 production
GO:0032880 regulation of protein localization
GO:0034260 negative regulation of GTPase activity
GO:0042594 response to starvation
GO:0043005 neuron projection
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043267 negative regulation of potassium ion transport
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045471 response to ethanol
GO:0045860 positive regulation of protein kinase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046034 ATP metabolic process
GO:0051428 peptide hormone receptor binding
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060078 regulation of postsynaptic membrane potential
GO:0060124 positive regulation of growth hormone secretion
GO:0060253 negative regulation of glial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070445 regulation of oligodendrocyte progenitor proliferation
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0090274 positive regulation of somatostatin secretion
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000532 Glucagon/GIP/secretin/VIPDomainDomain
IPR039080 Pituitary adenylate cyclase-activating polypeptideFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB03988 2,6-Diamino-Hexanoic Acid AmideDrugbanksmall molecule