Entity Details

Primary name CNRG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18545
EntryNameCNRG_HUMAN
FullNameRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
TaxID9606
Evidenceevidence at protein level
Length87
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesPDE6G

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004857 enzyme inhibitor activity
GO:0005886 plasma membrane
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007601 visual perception
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030507 spectrin binding
GO:0030553 cGMP binding
GO:0042622 photoreceptor outer segment membrane
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0097381 photoreceptor disc membrane

Subcellular Location

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Domains

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DomainNameCategoryType
IPR006952 Retinal cGMP phosphodiesterase, gamma subunitFamilyFamily
IPR037030 Retinal cGMP phosphodiesterase, gamma subunit superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613582 OMIMRetinitis pigmentosa 57 (RP57)A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00203 SildenafilDrugbanksmall molecule
DB00862 VardenafilDrugbanksmall molecule
DB07954 3-isobutyl-1-methyl-7H-xanthineDrugbanksmall molecule