Entity Details

Primary name SL9A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19634
EntryNameSL9A1_HUMAN
FullNameSodium/hydrogen exchanger 1
TaxID9606
Evidenceevidence at protein level
Length815
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesSLC9A1

GO terms

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GOName
GO:0005516 calmodulin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006811 ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0006885 regulation of pH
GO:0009986 cell surface
GO:0010447 response to acidic pH
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 intercalated disc
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0030011 maintenance of cell polarity
GO:0030027 lamellipodium
GO:0030214 hyaluronan catabolic process
GO:0030307 positive regulation of cell growth
GO:0030315 T-tubule
GO:0030346 protein phosphatase 2B binding
GO:0030674 protein-macromolecule adaptor activity
GO:0032869 cellular response to insulin stimulus
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035994 response to muscle stretch
GO:0036376 sodium ion export across plasma membrane
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045121 membrane raft
GO:0045760 positive regulation of action potential
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048306 calcium-dependent protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0051259 protein complex oligomerization
GO:0051453 regulation of intracellular pH
GO:0051492 regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0051930 regulation of sensory perception of pain
GO:0055007 cardiac muscle cell differentiation
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0070417 cellular response to cold
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0070997 neuron death
GO:0071236 cellular response to antibiotic
GO:0071257 cellular response to electrical stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071456 cellular response to hypoxia
GO:0071468 cellular response to acidic pH
GO:0071805 potassium ion transmembrane transport
GO:0071872 cellular response to epinephrine stimulus
GO:0086003 cardiac muscle cell contraction
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0086092 regulation of the force of heart contraction by cardiac conduction
GO:0090533 cation-transporting ATPase complex
GO:0098719 sodium ion import across plasma membrane
GO:0098735 positive regulation of the force of heart contraction
GO:1902600 proton transmembrane transport
GO:1903281 positive regulation of calcium:sodium antiporter activity

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Membrane

Domains

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DomainNameCategoryType
IPR001970 Na+/H+ exchanger, isoform 1 (NHE1)FamilyFamily
IPR004709 Na+/H+ exchangerFamilyFamily
IPR006153 Cation/H+ exchangerDomainDomain
IPR018422 Cation/H+ exchanger, CPA1 familyFamilyFamily
IPR032103 Sodium/hydrogen exchanger, regulatory regionDomainDomain

Diseases

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Disease IDSourceNameDescription
616291 OMIMLichtenstein-Knorr syndrome (LIKNS)An autosomal recessive neurologic disorder characterized by progressive cerebellar ataxia and severe progressive sensorineural hearing loss. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00594 AmilorideDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB02624 Homoserine LactoneDrugbanksmall molecule
DB06468 CariporideDrugbanksmall molecule