Entity Details

Primary name CR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20023
EntryNameCR2_HUMAN
FullNameComplement receptor type 2
TaxID9606
Evidenceevidence at protein level
Length1033
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCR2

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001848 complement binding
GO:0003677 DNA binding
GO:0004875 complement receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005886 plasma membrane
GO:0006955 immune response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0016021 integral component of membrane
GO:0030183 B cell differentiation
GO:0030449 regulation of complement activation
GO:0042100 B cell proliferation
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614699 OMIMImmunodeficiency, common variable, 7 (CVID7)A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. The disease is caused by variants affecting the gene represented in this entry.
610927 OMIMSystemic lupus erythematosus 9 (SLEB9)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variants affecting the gene represented in this entry.