Entity Details

Primary name AL5AP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20292
EntryNameAL5AP_HUMAN
FullNameArachidonate 5-lipoxygenase-activating protein
TaxID9606
Evidenceevidence at protein level
Length161
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesALOX5AP

GO terms

Show/Hide Table
GOName
GO:0004364 glutathione transferase activity
GO:0004464 leukotriene-C4 synthase activity
GO:0004602 glutathione peroxidase activity
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006691 leukotriene metabolic process
GO:0008047 enzyme activator activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0031965 nuclear membrane
GO:0047485 protein N-terminus binding
GO:0050544 arachidonic acid binding
GO:0070207 protein homotrimerization
GO:0071277 cellular response to calcium ion
GO:2001301 lipoxin biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Nucleus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) proteinFamilyFamily
IPR001446 5-lipoxygenase-activating proteinFamilyFamily
IPR018295 FLAP/GST2/LTC4S, conserved siteSiteConserved site
IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
601367 OMIMIschemic stroke (ISCHSTR)A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB04929 DG031Drugbanksmall molecule
DB05225 AM103Drugbanksmall molecule
DB06346 FiboflaponDrugbanksmall molecule