Entity Details

Primary name EDN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20800
EntryNameEDN2_HUMAN
FullNameEndothelin-2
TaxID9606
Evidenceevidence at protein level
Length178
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEDN2

GO terms

Show/Hide Table
GOName
GO:0001516 prostaglandin biosynthetic process
GO:0001659 temperature homeostasis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0003058 hormonal regulation of the force of heart contraction
GO:0003099 positive regulation of the force of heart contraction by chemical signal
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006874 cellular calcium ion homeostasis
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0010460 positive regulation of heart rate
GO:0014824 artery smooth muscle contraction
GO:0014826 vein smooth muscle contraction
GO:0019221 cytokine-mediated signaling pathway
GO:0019229 regulation of vasoconstriction
GO:0019722 calcium-mediated signaling
GO:0030593 neutrophil chemotaxis
GO:0031708 endothelin B receptor binding
GO:0042116 macrophage activation
GO:0042310 vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0048016 inositol phosphate-mediated signaling
GO:0048246 macrophage chemotaxis
GO:0048286 lung alveolus development
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0097009 energy homeostasis

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001928 Endothelin-like toxinDomainDomain
IPR015658 Endothelin-2FamilyFamily
IPR019764 Endothelin-like toxin, conserved siteSiteConserved site
IPR020475 EndothelinFamilyFamily

Diseases

Show/Hide Table

Interactions

3 interactions