Entity Details

Primary name AOFA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21397
EntryNameAOFA_HUMAN
FullNameAmine oxidase [flavin-containing] A
TaxID9606
Evidenceevidence at protein level
Length527
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesMAOA

GO terms

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GOName
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006576 cellular biogenic amine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008131 primary amine oxidase activity
GO:0009967 positive regulation of signal transduction
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0042133 neurotransmitter metabolic process
GO:0042135 neurotransmitter catabolic process
GO:0042420 dopamine catabolic process
GO:0097621 monoamine oxidase activity

Subcellular Location

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Subcellular Location
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR001613 Flavin amine oxidaseFamilyFamily
IPR002937 Amine oxidaseDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300615 OMIMBrunner syndrome (BRNRS)A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00140 RiboflavinDrugbanksmall molecule
DB00182 AmphetamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00191 PhentermineDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00388 PhenylephrineDrugbanksmall molecule
DB00397 PhenylpropanolamineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00601 LinezolidSwissprotsmall molecule
DB00614 FurazolidoneSwissprotsmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00669 SumatriptanDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00752 TranylcypromineDrugbanksmall molecule
DB00780 PhenelzineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB00952 NaratriptanDrugbanksmall molecule
DB00953 RizatriptanDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01168 ProcarbazineDrugbanksmall molecule
DB01171 MoclobemideDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01247 IsocarboxazidDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01442 MMDADrugbanksmall molecule
DB01445 BufotenineSwissprotsmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB01626 PargylineDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB04017 ClorgilineDrugbanksmall molecule
DB04818 IproniazidSwissprotsmall molecule
DB04820 NialamideDrugbanksmall molecule
DB04821 NomifensineDrugbanksmall molecule
DB04832 ZimelidineDrugbanksmall molecule
DB04850 PosizolidDrugbanksmall molecule
DB04889 BicifadineDrugbanksmall molecule
DB05205 CX157Drugbanksmall molecule
DB06412 OxymetholoneDrugbanksmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06698 BetahistineDrugbanksmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB07641 Decyl(dimethyl)phosphine oxideDrugbanksmall molecule
DB07919 HarmineDrugbanksmall molecule
DB08804 Nandrolone decanoateDrugbanksmall molecule
DB09042 Tedizolid phosphateSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule
DB09244 PirlindoleDrugbanksmall molecule
DB09245 ToloxatoneDrugbanksmall molecule
DB09363 Rauwolfia serpentina rootDrugbanksmall molecule
DB12329 EravacyclineDrugbanksmall molecule
DB13876 BrofaromineDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB14569 TedizolidSwissprotsmall molecule
DB14914 Flortaucipir F-18Drugbanksmall molecule
DB15328 UbrogepantDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AOFA_HUMANAOFA_HUMANHPRD16129825 details