Entity Details

Primary name SYT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21579
EntryNameSYT1_HUMAN
FullNameSynaptotagmin-1
TaxID9606
Evidenceevidence at protein level
Length422
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesSYT1

GO terms

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GOName
GO:0000149 SNARE binding
GO:0001786 phosphatidylserine binding
GO:0005509 calcium ion binding
GO:0005513 detection of calcium ion
GO:0005516 calmodulin binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006836 neurotransmitter transport
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007420 brain development
GO:0008021 synaptic vesicle
GO:0008022 protein C-terminus binding
GO:0014059 regulation of dopamine secretion
GO:0016192 vesicle-mediated transport
GO:0017075 syntaxin-1 binding
GO:0017156 calcium-ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0019905 syntaxin binding
GO:0030154 cell differentiation
GO:0030276 clathrin binding
GO:0030285 integral component of synaptic vesicle membrane
GO:0030348 syntaxin-3 binding
GO:0030424 axon
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031045 dense core granule
GO:0033603 positive regulation of dopamine secretion
GO:0042584 chromaffin granule membrane
GO:0042734 presynaptic membrane
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0044306 neuron projection terminus
GO:0046982 protein heterodimerization activity
GO:0048278 vesicle docking
GO:0048306 calcium-dependent protein binding
GO:0048488 synaptic vesicle endocytosis
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050806 positive regulation of synaptic transmission
GO:0051291 protein heterooligomerization
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060076 excitatory synapse
GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane
GO:0060203 clathrin-sculpted glutamate transport vesicle membrane
GO:0061024 membrane organization
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0061669 spontaneous neurotransmitter secretion
GO:0061891 calcium ion sensor activity
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
GO:0070382 exocytic vesicle
GO:0071277 cellular response to calcium ion
GO:0071911 synchronous neurotransmitter secretion
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter
GO:0098978 glutamatergic synapse
GO:0099502 calcium-dependent activation of synaptic vesicle fusion
GO:1903235 positive regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903305 regulation of regulated secretory pathway
GO:1903861 positive regulation of dendrite extension

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR001565 SynaptotagminDomainDomain
IPR015428 Synaptotagmin 1FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618218 OMIMBaker-Gordon syndrome (BAGOS)An autosomal dominant neurodevelopmental disorder characterized by infantile hypotonia, congenital ophthalmic abnormalities, involuntary and hyperkinetic movements, stereotypic behavior, poor or absent speech, EEG abnormalities, and global developmental delay varying in severity from moderate to profound. Behavioral characteristics include sleep disturbance and episodic agitation. The disease is caused by variants affecting the gene represented in this entry.

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
SYT1_HUMANSTON2_HUMANBioGRID, HPRD, IntAct11381094 11454741 14726597 details
SYT1_HUMANGOLM1_HUMANBioGRID, HPRD, IntAct16169070 details
SYT1_HUMANCACB4_HUMANHPRD, IntAct16525042 details
SYT1_HUMANCACB3_HUMANHPRD, IntAct16525042 details
SYT1_HUMANSMAD2_HUMANBioGRID, IntAct20195357 details
SYT1_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
SYT1_HUMANGIMA5_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANTM14C_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANHMOX2_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANMIP_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANUBIA1_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANBT2A2_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANZFPL1_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANCYB5B_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANTM254_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANBNIP2_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANTMM60_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANCGAT2_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANSNAB_HUMANBioGRID, IntAct32296183 details
SYT1_HUMANTSHR_HUMANBioGRID, MINT28298427 details
SYT1_HUMANDNJC5_HUMANBioGRID, IntAct29997244 details
SYT1_HUMANSNP25_HUMANBioGRID, HPRD, MINT10692432 12062043 22890573 30610939 details
SYT1_HUMANS10AD_HUMANBioGRID, HPRD11432880 12135982 9712836 details
SYT1_HUMANCALM1_HUMANBioGRID, HPRD8901523 details
SYT1_HUMANCALM2_HUMANBioGRID, HPRD8901523 details
SYT1_HUMANCALM3_HUMANBioGRID, HPRD8901523 details
SYT1_HUMANSTX1A_HUMANBioGRID, HPRD10397765 11438523 9010211 details
SYT1_HUMANHNRPQ_HUMANBioGRID, HPRD10734137 details
SYT1_HUMANCAC1A_HUMANBioGRID, HPRD9303303 details
SYT1_HUMANSTX2_HUMANBioGRID10397765 details
SYT1_HUMANSTX3_HUMANBioGRID10397765 details
SYT1_HUMANSTX4_HUMANBioGRID10397765 details
SYT1_HUMANFGF1_HUMANBioGRID, HPRD11432880 details
SYT1_HUMANRBM14_HUMANBioGRID15919756 details
SYT1_HUMANSIN3A_HUMANBioGRID15467731 details
SYT1_HUMANNEDD4_HUMANBioGRID19953087 details
SYT1_HUMANCBP_HUMANBioGRID32238831 details
SYT1_HUMANGCR_HUMANHPRD16143103 details
SYT1_HUMANPPARG_HUMANHPRD16143103 details
SYT1_HUMANNR1H3_HUMANHPRD16143103 details
SYT1_HUMANPEBB_HUMANIntAct20195357 details
SYT1_HUMANTFCP2_HUMANIntAct20195357 details
SYT1_HUMANPHS_HUMANIntAct20195357 details
SYT1_HUMANCSN4_HUMANMINT21102408 details
SYT1_HUMANFMR1_HUMANIntAct31413325 details
SYT1_HUMANSV2B_HUMANBioGRID, HPRD15466855 details
SYT1_HUMANCF015_HUMANBioGRID15466855 details
SYT1_HUMANSV2C_HUMANBioGRID15466855 details
SYT1_HUMANVAMP2_HUMANBioGRID22890573 details
SYT1_HUMANRB33A_HUMANBioGRID22740627 details
SYT1_HUMANA16L1_HUMANBioGRID22740627 details
SYT1_HUMANCMGA_HUMANBioGRID22740627 details
SYT1_HUMANRB27A_HUMANBioGRID22740627 details
SYT1_HUMANRACK1_HUMANHPRD1326322 details
SYT1_HUMANSYT1_HUMANHPRD11243866 8901523 details
SYT1_HUMANSYT4_HUMANHPRD10397765 details
SYT1_HUMANNRX1A_HUMANHPRD11243866 8901523 details
SYT1_HUMANAP2A_HUMANHPRD8087843 details
SYT1_HUMANIRF3_HUMANHPRD16143103 details
SYT1_HUMANRIMS1_HUMANHPRD11438520 details