Entity Details

Primary name TAF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21675
EntryNameTAF1_HUMAN
FullNameTranscription initiation factor TFIID subunit 1
TaxID9606
Evidenceevidence at protein level
Length1872
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesTAF1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0000785 chromatin
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001181 RNA polymerase I general transcription initiation factor activity
GO:0002039 p53 binding
GO:0004402 histone acetyltransferase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005669 transcription factor TFIID complex
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0016032 viral process
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0016301 kinase activity
GO:0017025 TBP-class protein binding
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030901 midbrain development
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034644 cellular response to UV
GO:0036369 transcription factor catabolic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0050821 protein stabilization
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
GO:0061631 ubiquitin conjugating enzyme activity
GO:0070577 lysine-acetylated histone binding
GO:0071318 cellular response to ATP
GO:0071339 MLL1 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0140416 transcription regulator inhibitor activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1905524 negative regulation of protein autoubiquitination
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000825 positive regulation of androgen receptor activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001487 BromodomainDomainDomain
IPR009067 TAFII-230 TBP-bindingDomainDomain
IPR011177 Transcription initiation factor TFIID subunit 1, animalFamilyFamily
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR022591 Transcription initiation factor TFIID subunit 1, domain of unknown functionDomainDomain
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR036741 TAFII-230 TBP-binding domain superfamilyFamilyHomologous superfamily
IPR040240 Transcription initiation factor TFIID subunit 1FamilyFamily
IPR041670 Zinc knuckleDomainDomain

Diseases

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Disease IDSourceNameDescription
300966 OMIMMental retardation, X-linked, syndromic, 33 (MRXS33)A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, delayed speech and language, and characteristic facial features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.
314250 OMIMDystonia 3, torsion, X-linked (DYT3)An X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
TAF1_HUMANRB_HUMANBioGRID, HPRD, IntAct11126356 7724524 9242374 9858607 details
TAF1_HUMANT2FA_HUMANBioGRID, HPRD, IntAct10428810 15053879 7590250 8625415 9482861 9660973 9858607 details
TAF1_HUMANTBP_HUMANBioGRID, DIP, HPRD, IntAct, MINT15564746 15870300 17375202 17884155 17967894 18391197 19240132 29111974 31753913 7597030 7680771 8858156 8995708 9153318 9311784 9603525 9660973 9674425 9858607 details
TAF1_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
TAF1_HUMANBRMS1_HUMANBioGRID, IntAct16919237 details
TAF1_HUMANAPC_HUMANBioGRID, IntAct20936779 details
TAF1_HUMANMAX_HUMANBioGRID, IntAct20936779 details
TAF1_HUMANRBP2_HUMANBioGRID, IntAct20936779 details
TAF1_HUMANMRCKA_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANCLIP4_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANDNJB5_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANDOCK9_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANITB5_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANMYOM2_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANKPCD3_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANSGCA_HUMANBioGRID, IntAct23414517 details
TAF1_HUMANTAF7L_HUMANBioGRID, IntAct12665565 28514442 31753913 details
TAF1_HUMANTAF7_HUMANBioGRID, DIP, HPRD11592977 14580349 18391197 22939629 29111974 31753913 details
TAF1_HUMANTAF2_HUMANBioGRID, DIP, HPRD10469661 14580349 15870300 22939629 29111974 7680771 details
TAF1_HUMANH31_HUMANBioGRID, IntAct14731392 20393127 29568061 details
TAF1_HUMANUBF1_HUMANBioGRID, HPRD12498690 details
TAF1_HUMANCCND1_HUMANBioGRID, HPRD11126356 9926939 details
TAF1_HUMANTAF6_HUMANBioGRID, HPRD12453419 14580349 22939629 26344197 29111974 31753913 7667268 details
TAF1_HUMANMDM2_HUMANBioGRID, HPRD17237821 9388200 details
TAF1_HUMANTAF4_HUMANBioGRID, HPRD11564872 14580349 22939629 26344197 29111974 31753913 details
TAF1_HUMANT2EA_HUMANBioGRID7926747 details
TAF1_HUMANFOS_HUMANBioGRID, HPRD8065335 details
TAF1_HUMANTF2AA_HUMANBioGRID, HPRD11278496 details
TAF1_HUMANTF65_HUMANBioGRID, HPRD9584164 details
TAF1_HUMANJUN_HUMANBioGRID, HPRD11316804 details
TAF1_HUMANP53_HUMANBioGRID10359315 15053879 details
TAF1_HUMANASF1A_HUMANBioGRID, HPRD12093919 20393127 details
TAF1_HUMANH4_HUMANBioGRID14731392 20393127 27248496 details
TAF1_HUMANPAX3_HUMANBioGRID21145483 details
TAF1_HUMANANDR_HUMANBioGRID20181722 details
TAF1_HUMANH31T_HUMANBioGRID, HPRD17884155 20850016 8980232 details
TAF1_HUMANTAF4B_HUMANBioGRID15601843 29111974 31753913 details
TAF1_HUMANUBC9_HUMANBioGRID15637059 details
TAF1_HUMANH11_HUMANBioGRID21145483 details
TAF1_HUMANSPTN1_HUMANBioGRID17607528 details
TAF1_HUMANLHX3_HUMANBioGRID23861948 details
TAF1_HUMANSUMO2_HUMANBioGRID32786267 details
TAF1_HUMANASF1B_HUMANHPRD12842904 details
TAF1_HUMANWDR5_HUMANBioGRID, UniProt15960975 32076268 details
TAF1_HUMANTAF8_HUMANBioGRID, HPRD, IntAct14580349 26186194 28514442 29111974 31753913 details
TAF1_HUMANTAF10_HUMANBioGRID, DIP, HPRD14580349 17643375 23292512 29111974 7923369 details
TAF1_HUMANTAF5_HUMANBioGRID, DIP, HPRD14580349 22939629 26344197 29111974 31753913 7680771 9045704 details
TAF1_HUMANFMR1_HUMANIntAct31413325 details
TAF1_HUMANDISC1_HUMANIntAct31413325 details
TAF1_HUMANA4_HUMANIntAct31413325 details
TAF1_HUMANPAX6_HUMANBioGRID10359315 details
TAF1_HUMANRBL1_HUMANBioGRID, HPRD9242374 details
TAF1_HUMANRBL2_HUMANBioGRID, HPRD9242374 details
TAF1_HUMANTAF9_HUMANBioGRID, HPRD11564863 14580349 29111974 31753913 details
TAF1_HUMANCSK21_HUMANBioGRID18548200 details
TAF1_HUMANTAF13_HUMANBioGRID17643375 29111974 31753913 details
TAF1_HUMANSIN3A_HUMANBioGRID12453419 details
TAF1_HUMANSMCA2_HUMANBioGRID12453419 details
TAF1_HUMANPHF8_HUMANBioGRID20421419 details
TAF1_HUMANMEN1_HUMANBioGRID14992727 details
TAF1_HUMANTAF9B_HUMANBioGRID15899866 22939629 29111974 details
TAF1_HUMANTAF3_HUMANBioGRID22939629 26344197 29111974 31753913 details
TAF1_HUMANKMT2A_HUMANBioGRID12453419 details
TAF1_HUMANTAF11_HUMANBioGRID, HPRD14580349 29111974 details
TAF1_HUMANTAF1_HUMANBioGRID, HPRD29111974 8650542 details
TAF1_HUMANBEX2_HUMANBioGRID16314316 details
TAF1_HUMANRBTN2_HUMANBioGRID16314316 details
TAF1_HUMANLDB1_HUMANBioGRID16314316 details
TAF1_HUMANTAF12_HUMANBioGRID, HPRD14580349 31753913 details
TAF1_HUMANCDC27_HUMANBioGRID32076268 details
TAF1_HUMANTCP4_HUMANHPRD9482861 details
TAF1_HUMANRBP56_HUMANHPRD8663456 9488465 details
TAF1_HUMANEDF1_HUMANHPRD12040021 details
TAF1_HUMANCCNA2_HUMANHPRD9660973 details
TAF1_HUMANEWS_HUMANHPRD9488465 details
TAF1_HUMANHSF1_HUMANHPRD11005381 details
TAF1_HUMANMSX1_HUMANHPRD8700832 details
TAF1_HUMANHMGB1_HUMANHPRD11748221 9880542 details