Entity Details

Primary name KCNA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22459
EntryNameKCNA4_HUMAN
FullNamePotassium voltage-gated channel subfamily A member 4
TaxID9606
Evidenceevidence at protein level
Length653
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesKCNA4

GO terms

Show/Hide Table
GOName
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006813 potassium ion transport
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030955 potassium ion binding
GO:0034765 regulation of ion transmembrane transport
GO:0043197 dendritic spine
GO:0051260 protein homooligomerization
GO:0071805 potassium ion transmembrane transport

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection

Domains

Show/Hide Table
DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR003131 Potassium channel tetramerisation-type BTB domainDomainDomain
IPR003968 Potassium channel, voltage dependent, KvFamilyFamily
IPR003972 Potassium channel, voltage dependent, Kv1FamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR012897 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domainDomainDomain
IPR020467 Potassium channel, voltage dependent, Kv1.4FamilyFamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR028325 Voltage-gated potassium channelFamilyFamily
IPR037065 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618284 OMIMMicrocephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum (MCIDDS)An autosomal recessive syndrome characterized by cognitive impairment, attention deficit hyperactivity disorder, microcephaly, growth retardation, congenital cataract, and dystonia. Brain MRI shows unusual thinning of the lentiform nucleus, predominantly involving the putamen, and swelling in the caudate heads. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB02299 ArginineamideDrugbanksmall molecule
DB06637 DalfampridineDrugbanksmall molecule