Entity Details

Primary name SYWC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23381
EntryNameSYWC_HUMAN
FullNameTryptophan--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length471
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesWARS1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
GO:0006469 negative regulation of protein kinase activity
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010835 regulation of protein ADP-ribosylation
GO:0019210 kinase inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032991 protein-containing complex
GO:0042803 protein homodimerization activity
GO:0045765 regulation of angiogenesis
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002305 Aminoacyl-tRNA synthetase, class IcFamilyFamily
IPR002306 Tryptophan-tRNA ligaseFamilyFamily
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617721 OMIMNeuronopathy, distal hereditary motor, 9 (HMN9)An autosomal dominant neurologic disorder characterized by juvenile onset of slowly progressive distal muscle weakness and atrophy affecting both the lower and upper limbs. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00150 TryptophanDrugbanksmall molecule
DB01831 Tryptophanyl-5'ampDrugbanksmall molecule
DB04537 TryptophanamideDrugbanksmall molecule