Entity Details

Primary name KTHY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23919
EntryNameKTHY_HUMAN
FullNameThymidylate kinase
TaxID9606
Evidenceevidence at protein level
Length212
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesDTYMK

GO terms

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GOName
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009041 uridylate kinase activity
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043627 response to estrogen
GO:0045445 myoblast differentiation
GO:0046105 thymidine biosynthetic process
GO:0046686 response to cadmium ion
GO:0071363 cellular response to growth factor stimulus

Subcellular Location

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Domains

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DomainNameCategoryType
IPR018094 Thymidylate kinaseFamilyFamily
IPR018095 Thymidylate kinase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR039430 Thymidylate kinase-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01643 Thymidine monophosphateDrugbanksmall molecule
DB03150 2',3'-Dideoxythymidine-5'-MonophosphateDrugbanksmall molecule
DB03195 3'-Fluoro-3'-deoxythymidine 5'-monophosphateDrugbanksmall molecule
DB03233 3'-deoxy-3'-aminothymidine monophosphateDrugbanksmall molecule
DB03280 p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphateDrugbanksmall molecule
DB03666 Zidovudine monophosphateDrugbanksmall molecule
DB03845 P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))PentaphosphateDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KTHY_HUMANDHB7_HUMANBioGRID, IntAct21988832 details