Entity Details

Primary name COT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24468
EntryNameCOT2_HUMAN
FullNameCOUP transcription factor 2
TaxID9606
Evidenceevidence at protein level
Length414
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesNR2F2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001764 neuron migration
GO:0001893 maternal placenta development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001972 retinoic acid binding
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007519 skeletal muscle tissue development
GO:0008270 zinc ion binding
GO:0008585 female gonad development
GO:0009566 fertilization
GO:0009952 anterior/posterior pattern specification
GO:0009956 radial pattern formation
GO:0010596 negative regulation of endothelial cell migration
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0032355 response to estradiol
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048514 blood vessel morphogenesis
GO:0048856 anatomical structure development
GO:0060173 limb development
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060838 lymphatic endothelial cell fate commitment

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615779 OMIMCongenital heart defects, multiple types, 4 (CHTD4)A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. The disease is caused by variants affecting the gene represented in this entry.
618901 OMIM46,XX sex reversal 5 (SRXX5)A condition in which male gonads develop in a genetic female (female to male sex reversal). Additional features in SRXX5 patients are congenital heart disease, congenital diaphragmatic hernia, and blepharophimosis-ptosis-epicanthus inversus syndrome. SRXX5 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.