Entity Details

Primary name KPCL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24723
EntryNameKPCL_HUMAN
FullNameProtein kinase C eta type
TaxID9606
Evidenceevidence at protein level
Length683
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCH

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0018105 peptidyl-serine phosphorylation
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035556 intracellular signal transduction
GO:0045618 positive regulation of keratinocyte differentiation
GO:0046872 metal ion binding
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060252 positive regulation of glial cell proliferation
GO:0070062 extracellular exosome
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014376 Protein kinase C, delta/epsilon/eta/theta typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR027431 Protein kinase C, etaFamilyFamily
IPR034665 Novel protein kinase C eta, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
601367 OMIMIschemic stroke (ISCHSTR)A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variants affecting the gene represented in this entry.