Entity Details

Primary name PTAFR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25105
EntryNamePTAFR_HUMAN
FullNamePlatelet-activating factor receptor
TaxID9606
Evidenceevidence at protein level
Length342
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesPTAFR

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0001875 lipopolysaccharide immune receptor activity
GO:0002693 positive regulation of cellular extravasation
GO:0004930 G protein-coupled receptor activity
GO:0004992 platelet activating factor receptor activity
GO:0005543 phospholipid binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007567 parturition
GO:0009609 response to symbiotic bacterium
GO:0010863 positive regulation of phospholipase C activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030667 secretory granule membrane
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032959 inositol trisphosphate biosynthetic process
GO:0043312 neutrophil degranulation
GO:0043315 positive regulation of neutrophil degranulation
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
GO:0045056 transcytosis
GO:0045727 positive regulation of translation
GO:0045776 negative regulation of blood pressure
GO:0045907 positive regulation of vasoconstriction
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051019 mitogen-activated protein kinase binding
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0070821 tertiary granule membrane
GO:0071258 cellular response to gravity
GO:0071320 cellular response to cAMP
GO:0071398 cellular response to fatty acid
GO:0071548 response to dexamethasone
GO:1902943 positive regulation of voltage-gated chloride channel activity
GO:1903238 positive regulation of leukocyte tethering or rolling
GO:1904058 positive regulation of sensory perception of pain
GO:1904300 positive regulation of transcytosis
GO:1904303 positive regulation of maternal process involved in parturition
GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction
GO:1904317 cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR002282 Platelet-activating factor receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02261 Platelet Activating FactorDrugbanksmall molecule
DB09166 EtizolamDrugbanksmall molecule
DB11614 RupatadineDrugbanksmall molecule