Entity Details

Primary name PAR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25116
EntryNamePAR1_HUMAN
FullNameProteinase-activated receptor 1
TaxID9606
Evidenceevidence at protein level
Length425
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesF2R

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001965 G-protein alpha-subunit binding
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0003105 negative regulation of glomerular filtration
GO:0004930 G protein-coupled receptor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007529 establishment of synaptic specificity at neuromuscular junction
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0009986 cell surface
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015057 thrombin-activated receptor activity
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0031094 platelet dense tubular network
GO:0031594 neuromuscular junction
GO:0031681 G-protein beta-subunit binding
GO:0032496 response to lipopolysaccharide
GO:0032651 regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0035025 positive regulation of Rho protein signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045211 postsynaptic membrane
GO:0045217 cell-cell junction maintenance
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048873 homeostasis of number of cells within a tissue
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051928 positive regulation of calcium ion transport
GO:0051930 regulation of sensory perception of pain
GO:0060155 platelet dense granule organization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
GO:1900134 negative regulation of renin secretion into blood stream

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000935 Thrombin receptorFamilyFamily
IPR003912 Protease-activated receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00086 StreptokinaseDrugbankbiotech
DB05361 SR-123781ADrugbanksmall molecule
DB09030 VorapaxarDrugbanksmall molecule
DB11300 ThrombinDrugbankbiotech

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
PAR1_HUMANCHRD_HUMANBioGRID, IntAct21988832 details
PAR1_HUMANAT132_HUMANBioGRID, IntAct22645275 details
PAR1_HUMANPAR1_HUMANDIP17376866 details
PAR1_HUMANPAR3_HUMANDIP17376866 details
PAR1_HUMANTHRB_HUMANDIP, HPRD10644723 10978167 12563219 18250335 9058715 details
PAR1_HUMANSNX1_HUMANBioGRID, HPRD12058063 details
PAR1_HUMANPDC6I_HUMANBioGRID22547407 22833563 26490116 details
PAR1_HUMANARRD3_HUMANBioGRID26490116 details
PAR1_HUMANCXL14_HUMANBioGRID30204129 details
PAR1_HUMANCAV1_HUMANBioGRID, UniProt17848177 20826780 details
PAR1_HUMANEPCR_HUMANBioGRID, DIP, UniProt17299037 20826780 details
PAR1_HUMANTMED2_HUMANUniProt21219331 details
PAR1_HUMANCAN1_HUMANBioGRID, HPRD, IntAct10978167 25241761 details
PAR1_HUMANGNA13_HUMANBioGRID, HPRD, Molecular Connections10922491 23773523 8290554 details
PAR1_HUMANGNA12_HUMANBioGRID, HPRD8290554 details
PAR1_HUMANCHM4A_HUMANBioGRID22547407 details
PAR1_HUMANGNAQ_HUMANBioGRID8982657 details
PAR1_HUMANGNAI2_HUMANBioGRID, HPRD10644723 8982657 details
PAR1_HUMANFLOT2_HUMANBioGRID15492257 details
PAR1_HUMANAP3D1_HUMANBioGRID22833563 details
PAR1_HUMANMK14_HUMANBioGRID26391660 details
PAR1_HUMANTAB1_HUMANBioGRID26391660 details
PAR1_HUMANTAB2_HUMANBioGRID26391660 details
PAR1_HUMANITAV_HUMANHPRD11278329 details
PAR1_HUMANCATG_HUMANHPRD10978167 details
PAR1_HUMANGNAT1_HUMANHPRD10583385 details
PAR1_HUMANPLMN_HUMANHPRD10978167 details
PAR1_HUMANELNE_HUMANHPRD10978167 details
PAR1_HUMANPRTN3_HUMANHPRD10978167 details
PAR1_HUMANGASP1_HUMANHPRD15452121 details
PAR1_HUMANGNA15_HUMANHPRD10644723 details