Entity Details

Primary name PSA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25789
EntryNamePSA4_HUMAN
FullNameProteasome subunit alpha type-4
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesPSMA4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000426 Proteasome alpha-subunit, N-terminal domainDomainDomain
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR023332 Proteasome alpha-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR034647 Proteasome subunit alpha4FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDrugbanksmall molecule

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
PSA4_HUMANPSA2_HUMANBioGRID, HPRD, IntAct, MINT12376572 14733938 15225636 15887188 17948026 19193609 22863883 22939629 26344197 28292943 31114588 9311996 details
PSA4_HUMANPSA3_HUMANBioGRID, HPRD, IntAct14733938 15225636 22863883 22939629 26344197 9311996 details
PSA4_HUMANPSA7_HUMANBioGRID, HPRD, IntAct, MINT14733938 15225636 17948026 22863883 22939629 26344197 27465334 28292943 32296183 9311996 details
PSA4_HUMANPSA1_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 15225636 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 9311996 details
PSA4_HUMANPSA4_HUMANBioGRID, HPRD, IntAct15225636 28292943 details
PSA4_HUMANPOMP_HUMANBioGRID, MINT17948026 26344197 details
PSA4_HUMANGOGA2_HUMANBioGRID, IntAct25416956 details
PSA4_HUMANIKZF1_HUMANBioGRID, IntAct25416956 32296183 details
PSA4_HUMANTRI38_HUMANBioGRID, IntAct32296183 details
PSA4_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
PSA4_HUMANREL_HUMANBioGRID, IntAct32296183 details
PSA4_HUMANCARD9_HUMANBioGRID, IntAct32296183 details
PSA4_HUMANATX1_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
PSA4_HUMANHD_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
PSA4_HUMANCSK21_HUMANBioGRID, HPRD8619999 details
PSA4_HUMANPLK1_HUMANBioGRID, HPRD11205743 details
PSA4_HUMANPRKN_HUMANBioGRID15987638 16714300 23503661 details
PSA4_HUMANPRS8_HUMANBioGRID22939629 26344197 28292943 details
PSA4_HUMANPSD11_HUMANBioGRID22939629 28292943 details
PSA4_HUMANPRS4_HUMANBioGRID22939629 26344197 28292943 details
PSA4_HUMANRHOU_HUMANBioGRID26598620 details
PSA4_HUMANTRAF6_HUMANIntAct14743216 details
PSA4_HUMANPSA6_HUMANBioGRID, DIP, HPRD, IntAct, MINT15225636 16759355 17948026 19581590 22863883 22939629 26344197 9311996 details
PSA4_HUMANPSA5_HUMANBioGRID, HPRD, IntAct15225636 22863883 22939629 26344197 9311996 details
PSA4_HUMANPSB7_HUMANBioGRID, IntAct16423992 20723761 22863883 22939629 26186194 26344197 28514442 9311996 details
PSA4_HUMANCUL1_HUMANBioGRID, IntAct16759355 21145461 details
PSA4_HUMANPSB9_HUMANBioGRID, IntAct26186194 28514442 30833792 9311996 details
PSA4_HUMANPSB1_HUMANBioGRID, IntAct22863883 22939629 26344197 28514442 9311996 details
PSA4_HUMANPSB4_HUMANBioGRID, IntAct22863883 22939629 26186194 26344197 28514442 9311996 details
PSA4_HUMANPSB2_HUMANBioGRID, IntAct22863883 22939629 26344197 28514442 32723828 details
PSA4_HUMANHIF1A_HUMANBioGRID, DIP22801492 27918549 details
PSA4_HUMANIKBA_HUMANBioGRID, DIP24509793 9875328 details
PSA4_HUMANRD23A_HUMANBioGRID19013454 details
PSA4_HUMANPSB5_HUMANBioGRID22863883 22939629 26344197 9311996 details
PSA4_HUMANPSB6_HUMANBioGRID22863883 22939629 26344197 9311996 details
PSA4_HUMANPSB8_HUMANBioGRID15303969 22863883 22939629 26344197 9311996 details
PSA4_HUMANNFKB1_HUMANBioGRID8692272 details
PSA4_HUMANABL1_HUMANBioGRID16678104 details
PSA4_HUMANFKBP8_HUMANBioGRID17573772 details
PSA4_HUMANNEDD8_HUMANBioGRID16503656 details
PSA4_HUMANBHE41_HUMANBioGRID22801492 details
PSA4_HUMANPSME2_HUMANBioGRID11745344 details
PSA4_HUMANPSME1_HUMANBioGRID11745344 details
PSA4_HUMANPSDE_HUMANBioGRID17323924 22939629 26344197 27428775 28821611 32723828 details
PSA4_HUMANPSME3_HUMANBioGRID22939629 29934401 details
PSA4_HUMANASB10_HUMANBioGRID23901248 details
PSA4_HUMANU2AF2_HUMANBioGRID26344197 26641092 details
PSA4_HUMANHERC3_HUMANBioGRID26476452 details
PSA4_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSA4_HUMANCO2_HUMANHPRD8175701 details