Entity Details

Primary name MOES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26038
EntryNameMOES_HUMAN
FullNameMoesin
TaxID9606
Evidenceevidence at protein level
Length577
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesMSN

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0001931 uropod
GO:0003725 double-stranded RNA binding
GO:0003779 actin binding
GO:0005102 signaling receptor binding
GO:0005200 structural constituent of cytoskeleton
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005925 focal adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0022612 gland morphogenesis
GO:0022614 membrane to membrane docking
GO:0030175 filopodium
GO:0031143 pseudopodium
GO:0031528 microvillus membrane
GO:0031982 vesicle
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042098 T cell proliferation
GO:0045177 apical part of cell
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0048471 perinuclear region of cytoplasm
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0061028 establishment of endothelial barrier
GO:0070062 extracellular exosome
GO:0070489 T cell aggregation
GO:0071394 cellular response to testosterone stimulus
GO:0071803 positive regulation of podosome assembly
GO:0071944 cell periphery
GO:0072562 blood microparticle
GO:0072678 T cell migration
GO:1902115 regulation of organelle assembly
GO:1902966 positive regulation of protein localization to early endosome
GO:1903364 positive regulation of cellular protein catabolic process
GO:2000401 regulation of lymphocyte migration
GO:2000643 positive regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Disease IDSourceNameDescription
300988 OMIMImmunodeficiency 50 (IMD50)A primary immunodeficiency disorder characterized by onset of recurrent bacterial or varicella zoster virus infections in early childhood, profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and neutropenia, and a poor immune response to vaccine antigens. The disease is caused by variants affecting the gene represented in this entry.

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
MOES_HUMANNHRF1_HUMANBioGRID, HPRD, IntAct15020681 9430655 details
MOES_HUMANCD11B_HUMANBioGRID, IntAct21988832 details
MOES_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
MOES_HUMANVCAM1_HUMANBioGRID, HPRD, IntAct12082081 19738201 22623428 23463506 7884872 details
MOES_HUMANLRRK2_HUMANBioGRID, IntAct20642453 22363216 22952686 23241358 24351927 24695735 24904275 25009464 26824392 27357661 31046837 details
MOES_HUMANCD44_HUMANBioGRID, Molecular Connections23855374 9472040 details
MOES_HUMANEZRI_HUMANBioGRID, HPRD, IntAct15659383 26496610 29568061 34079125 7579708 8248180 details
MOES_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
MOES_HUMANRBTN2_HUMANBioGRID, IntAct32296183 details
MOES_HUMANPCNA_HUMANUniProt26030842 details
MOES_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
MOES_HUMANCRUM1_HUMANUniProt17920587 details
MOES_HUMANTSC1_HUMANBioGRID, HPRD12226091 details
MOES_HUMANICAM3_HUMANBioGRID, HPRD11784723 23463506 9298994 details
MOES_HUMANNCF1_HUMANBioGRID, HPRD10436021 11716484 details
MOES_HUMANNCF4_HUMANBioGRID, HPRD11716484 details
MOES_HUMANLYAM1_HUMANBioGRID, HPRD11706008 details
MOES_HUMANLEUK_HUMANBioGRID, HPRD9472040 9616160 details
MOES_HUMANICAM2_HUMANBioGRID, HPRD9472040 details
MOES_HUMANSELPL_HUMANBioGRID12115638 details
MOES_HUMANVPS11_HUMANBioGRID21148287 details
MOES_HUMANTRI15_HUMANBioGRID25450970 details
MOES_HUMANSMUF1_HUMANBioGRID20804422 details
MOES_HUMANHLAC_HUMANIntAct17353931 details
MOES_HUMANSYUG_HUMANIntAct17353931 details
MOES_HUMANELF3_HUMANIntAct17353931 details
MOES_HUMANIKKE_HUMANIntAct17353931 details
MOES_HUMANAAKB1_HUMANIntAct17353931 details
MOES_HUMANCDK2_HUMANBioGRID, IntAct17353931 21319273 details
MOES_HUMANTRAF6_HUMANIntAct17353931 details
MOES_HUMANKSYK_HUMANMINT12387735 details
MOES_HUMANBID_HUMANBioGRID15659383 details
MOES_HUMANTR10B_HUMANBioGRID15659383 details
MOES_HUMANFADD_HUMANBioGRID15659383 details
MOES_HUMANTNFL6_HUMANBioGRID15659383 details
MOES_HUMANMK08_HUMANBioGRID15659383 details
MOES_HUMANTNR6_HUMANBioGRID15659383 details
MOES_HUMANRHOA_HUMANBioGRID15659383 details
MOES_HUMANGDIR1_HUMANBioGRID15659383 26344197 details
MOES_HUMANCASPA_HUMANBioGRID15659383 details
MOES_HUMANCASP8_HUMANBioGRID15659383 details
MOES_HUMANTNR1A_HUMANBioGRID15659383 details
MOES_HUMANMOES_HUMANBioGRID, HPRD10847681 details
MOES_HUMANSPTN1_HUMANBioGRID11441066 details
MOES_HUMANMCP_HUMANBioGRID, HPRD12082081 7884872 details
MOES_HUMANISG15_HUMANBioGRID16009940 details
MOES_HUMANBRCA1_HUMANBioGRID21282464 details
MOES_HUMANICAM1_HUMANBioGRID, HPRD12082081 23463506 details
MOES_HUMANCD81_HUMANBioGRID23463506 details
MOES_HUMANIGSF8_HUMANBioGRID23463506 details
MOES_HUMANABCE1_HUMANBioGRID25659154 details
MOES_HUMANU2AF2_HUMANBioGRID26641092 details
MOES_HUMANPD1L1_HUMANBioGRID32941674 details
MOES_HUMANBAP31_HUMANHPRD12594175 details
MOES_HUMANL1CAM_HUMANHPRD12070130 details
MOES_HUMANKPCT_HUMANHPRD9516463 9856983 details
MOES_HUMANPLEC_HUMANHPRD11441066 details
MOES_HUMANROCK1_HUMANHPRD9516463 9856983 details
MOES_HUMANPPM1B_HUMANHPRD10480873 details
MOES_HUMANPPM1A_HUMANHPRD10480873 details
MOES_HUMANC1QR1_HUMANHPRD15819698 details