Entity Details

Primary name DNMT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26358
EntryNameDNMT1_HUMAN
FullNameDNA (cytosine-5)-methyltransferase 1
TaxID9606
Evidenceevidence at protein level
Length1616
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesDNMT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006306 DNA methylation
GO:0006325 chromatin organization
GO:0007265 Ras protein signal transduction
GO:0008270 zinc ion binding
GO:0009008 DNA-methyltransferase activity
GO:0010216 maintenance of DNA methylation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process
GO:1905931 negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001025 Bromo adjacent homology (BAH) domainDomainDomain
IPR001525 C-5 cytosine methyltransferaseFamilyFamily
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR010506 DMAP1-binding domainDomainDomain
IPR017198 DNA (cytosine-5)-methyltransferase 1-likeFamilyFamily
IPR018117 DNA methylase, C-5 cytosine-specific, active siteSiteActive site
IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR031303 DNA methylase, C-5 cytosine-specific, conserved siteSiteConserved site
IPR043151 Bromo adjacent homology (BAH) domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
604121 OMIMCerebellar ataxia, deafness, and narcolepsy, autosomal dominant (ADCADN)An autosomal dominant neurologic disorder characterized by adult onset of progressive cerebellar ataxia, narcolepsy, cataplexy, sensorineural deafness, and dementia. More variable features include optic atrophy, sensory neuropathy, psychosis, and depression. The disease is caused by variants affecting the gene represented in this entry.
614116 OMIMNeuropathy, hereditary sensory, 1E (HSN1E)A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00721 ProcaineDrugbanksmall molecule
DB00928 AzacitidineDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01099 FlucytosineDrugbanksmall molecule
DB01262 DecitabineDrugbanksmall molecule
DB05668 PalifosfamideDrugbanksmall molecule
DB12116 Epigallocatechin gallateDrugbanksmall molecule

Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
DNMT1_HUMANTRI27_HUMANBioGRID, HPRD, IntAct16169070 details
DNMT1_HUMANEZH2_HUMANBioGRID, HPRD, IntAct16357870 21378168 22094255 28068325 31130994 details
DNMT1_HUMANUHRF1_HUMANBioGRID, IntAct, MINT17673620 17934516 19798101 19800870 19943104 20613874 21045206 21268065 21745816 22064703 24368767 24782312 26065575 27045799 27049577 28803780 29268763 29691401 31322780 details
DNMT1_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct10615135 10888886 12473678 15870198 17707923 17934516 17967891 20613874 21670149 22274925 23708667 26794444 27593931 details
DNMT1_HUMANNRIP1_HUMANBioGRID, MINT17972916 details
DNMT1_HUMANUBP7_HUMANBioGRID, IntAct19615732 21045206 21268065 21745816 22411829 25753001 25960197 26496610 30367141 30804394 31130994 32884836 details
DNMT1_HUMANKAT2B_HUMANUniProt21947282 details
DNMT1_HUMANSIR1_HUMANBioGRID, IntAct, UniProt21947282 22094255 details
DNMT1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
DNMT1_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
DNMT1_HUMANKS6A6_HUMANBioGRID, MINT21900206 details
DNMT1_HUMANDNM3B_HUMANBioGRID, HPRD, IntAct12145218 12867029 15120635 21406692 22094255 27728808 29691401 details
DNMT1_HUMANBRAP_HUMANBioGRID, IntAct25820252 details
DNMT1_HUMANSETD7_HUMANBioGRID, DIP19282482 21151116 details
DNMT1_HUMANAKT1_HUMANBioGRID, DIP21151116 details
DNMT1_HUMANH31_HUMANBioGRID, IntAct26527279 29568061 32144273 32884836 34079125 details
DNMT1_HUMANRGS6_HUMANBioGRID14734556 details
DNMT1_HUMANCBX1_HUMANBioGRID, HPRD12711675 details
DNMT1_HUMANPCNA_HUMANBioGRID, HPRD10888872 12354094 20613874 20940144 22606318 23708667 24958773 26496610 30301766 9302295 details
DNMT1_HUMANHDAC2_HUMANBioGRID, HPRD10888872 17967891 21670149 23708667 details
DNMT1_HUMANDMAP1_HUMANBioGRID, HPRD10888872 details
DNMT1_HUMANRB_HUMANBioGRID, HPRD10888886 11847125 23280764 details
DNMT1_HUMANDNM3A_HUMANBioGRID, HPRD12145218 21406692 29691401 details
DNMT1_HUMANMECP2_HUMANBioGRID12473678 details
DNMT1_HUMANBAZ2A_HUMANBioGRID16085498 details
DNMT1_HUMANHELLS_HUMANBioGRID17967891 details
DNMT1_HUMANMTG8_HUMANBioGRID15735013 details
DNMT1_HUMANRUNX1_HUMANBioGRID15735013 28533407 details
DNMT1_HUMANPAF15_HUMANBioGRID21628590 32144273 details
DNMT1_HUMAN1433T_HUMANBioGRID15161933 details
DNMT1_HUMANH31T_HUMANBioGRID26065575 30104358 details
DNMT1_HUMANLASP1_HUMANBioGRID25982273 details
DNMT1_HUMANAAPK2_HUMANBioGRID28143904 details
DNMT1_HUMANCUL4B_HUMANBioGRID24292684 29691401 details
DNMT1_HUMANDDB1_HUMANBioGRID24292684 29691401 details
DNMT1_HUMANE2F6_HUMANBioGRID23082233 details
DNMT1_HUMANUBB_HUMANBioGRID29471350 details
DNMT1_HUMANDCAF5_HUMANBioGRID29691401 details
DNMT1_HUMANLMBL3_HUMANBioGRID29691401 details
DNMT1_HUMANSUMO2_HUMANBioGRID32786267 details
DNMT1_HUMANH2B1B_HUMANBioGRID32884836 details
DNMT1_HUMANTS101_HUMANHPRD10888872 details
DNMT1_HUMANEED_HUMANBioGRID, HPRD, IntAct16357870 22094255 details
DNMT1_HUMAN1433Z_HUMANMINT15161933 details
DNMT1_HUMANH2AX_HUMANIntAct22094255 27728808 details
DNMT1_HUMANCTNB1_HUMANIntAct25753001 details
DNMT1_HUMANPARP1_HUMANBioGRID, IntAct23708667 27728808 34079125 details
DNMT1_HUMANMTA2_HUMANBioGRID, IntAct21670149 23708667 27728808 details
DNMT1_HUMANMTA1_HUMANBioGRID, IntAct21670149 23708667 26344197 27728808 details
DNMT1_HUMANMBD2_HUMANBioGRID, IntAct10947852 27593931 details
DNMT1_HUMANH4_HUMANBioGRID, IntAct30021884 30804502 details
DNMT1_HUMANPICK1_HUMANMINT21653829 details
DNMT1_HUMANPEBP1_HUMANMINT21653829 details
DNMT1_HUMANPHC2_HUMANMINT21653829 details
DNMT1_HUMANMCRI1_HUMANMINT21653829 details
DNMT1_HUMANENSA_HUMANMINT21653829 details
DNMT1_HUMANEF1A1_HUMANMINT21653829 details
DNMT1_HUMANTRIM3_HUMANMINT21653829 details
DNMT1_HUMANNGRN_HUMANMINT21653829 details
DNMT1_HUMANCBX5_HUMANBioGRID12867029 17470536 details
DNMT1_HUMANSUV91_HUMANBioGRID, HPRD12711675 17085482 details
DNMT1_HUMANE2F1_HUMANBioGRID10888886 details
DNMT1_HUMANCXXC1_HUMANBioGRID18680430 details
DNMT1_HUMANSP1_HUMANBioGRID17124180 details
DNMT1_HUMANSP3_HUMANBioGRID17124180 details
DNMT1_HUMANEHMT2_HUMANBioGRID17085482 23708667 details
DNMT1_HUMANSTAT3_HUMANBioGRID15870198 25854163 details
DNMT1_HUMANSMCA5_HUMANBioGRID15313181 details
DNMT1_HUMANP53_HUMANBioGRID17991895 23038753 32807901 details
DNMT1_HUMANCHK1_HUMANBioGRID17991895 20940144 details
DNMT1_HUMANWT1_HUMANBioGRID21378168 details
DNMT1_HUMANSUZ12_HUMANBioGRID21378168 27634302 details
DNMT1_HUMANHSP74_HUMANBioGRID21745816 details
DNMT1_HUMANRUXG_HUMANBioGRID21745816 details
DNMT1_HUMANBIP_HUMANBioGRID21745816 details
DNMT1_HUMANRAD9A_HUMANBioGRID20940144 details
DNMT1_HUMANKAT5_HUMANBioGRID21045206 29268763 details
DNMT1_HUMANDAXX_HUMANBioGRID14978102 23038753 23548901 details
DNMT1_HUMANGA45A_HUMANBioGRID22135303 details
DNMT1_HUMANUHRF2_HUMANBioGRID22064703 27114453 29691401 details
DNMT1_HUMANTIF1B_HUMANBioGRID21670149 22055183 29955894 details
DNMT1_HUMANZFP57_HUMANBioGRID22055183 details
DNMT1_HUMANDNMT1_HUMANBioGRID, HPRD10888886 19173286 details
DNMT1_HUMANSH3K1_HUMANBioGRID19531213 details
DNMT1_HUMANKDM1A_HUMANBioGRID21670149 22278882 31130994 details
DNMT1_HUMANNR2C1_HUMANBioGRID21670149 details
DNMT1_HUMANNR2C2_HUMANBioGRID21670149 30463901 details
DNMT1_HUMANCHD4_HUMANBioGRID21670149 23708667 details
DNMT1_HUMANRBBP4_HUMANBioGRID21670149 details
DNMT1_HUMANMBD3_HUMANBioGRID21670149 details
DNMT1_HUMANDPOD3_HUMANBioGRID21670149 details
DNMT1_HUMANHDAC3_HUMANBioGRID21670149 details
DNMT1_HUMANRELB_HUMANBioGRID23548901 details
DNMT1_HUMANCTBP1_HUMANBioGRID17972916 details
DNMT1_HUMANH2A2C_HUMANBioGRID26065575 details
DNMT1_HUMANMRTFA_HUMANBioGRID25854163 details
DNMT1_HUMANCCNB1_HUMANBioGRID27030811 details
DNMT1_HUMANSNAI1_HUMANBioGRID26794444 28067227 details
DNMT1_HUMANRBBP7_HUMANBioGRID28143904 details
DNMT1_HUMANHIC1_HUMANBioGRID27720955 details
DNMT1_HUMANMYCN_HUMANBioGRID23280764 details
DNMT1_HUMANZBT7A_HUMANBioGRID23658227 details
DNMT1_HUMANBCOR_HUMANBioGRID23658227 details
DNMT1_HUMANRNF4_HUMANBioGRID29634367 details
DNMT1_HUMANCUL4A_HUMANBioGRID29691401 details
DNMT1_HUMANP20L1_HUMANBioGRID29691401 details
DNMT1_HUMANNCOR1_HUMANBioGRID30463901 details
DNMT1_HUMANFKBP4_HUMANBioGRID26602018 details
DNMT1_HUMANCDK5_HUMANBioGRID26602018 details
DNMT1_HUMANCD5R1_HUMANBioGRID26602018 details
DNMT1_HUMANZN263_HUMANBioGRID32051553 details
DNMT1_HUMANRELN_HUMANBioGRID25476119 details
DNMT1_HUMANDCE1_HUMANBioGRID25476119 details
DNMT1_HUMANBDNF_HUMANBioGRID25476119 details
DNMT1_HUMANHMGB1_HUMANHPRD11748221 details
DNMT1_HUMANDYL1_HUMANHPRD14760703 details