Entity Details

Primary name PSB9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28065
EntryNamePSB9_HUMAN
FullNameProteasome subunit beta type-9
TaxID9606
Evidenceevidence at protein level
Length219
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPSMB9

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019774 proteasome core complex, beta-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990111 spermatoproteasome complex
GO:2000116 regulation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000243 Peptidase T1A, proteasome beta-subunitFamilyFamily
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR023333 Proteasome B-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR034383 Proteasome subunit beta type 9FamilyFamily

Diseases

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Disease IDSourceNameDescription
617591 OMIMProteasome-associated autoinflammatory syndrome 3 (PRAAS3)An autoinflammatory disorder characterized by onset in early infancy and recurrent fever, nodular dermatitis, myositis, panniculitis-induced lipodystrophy, lymphadenopathy, and immune dysregulation. Variable accompanying features may include joint contractures, hepatosplenomegaly, anemia, thrombocytopenia, recurrent infections, autoantibodies, and hypergammaglobulinemia. Some patients may have intracranial calcifications. PRAAS3 inheritance is autosomal recessive or digenic. The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08889 CarfilzomibDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
PSB9_HUMANPSB7_HUMANBioGRID, IntAct14733938 16423992 17948026 20723761 26186194 28514442 30833792 details
PSB9_HUMANPOMP_HUMANBioGRID, IntAct14733938 17506986 17948026 26186194 28514442 30833792 details
PSB9_HUMANABCB5_HUMANIntAct15488952 details
PSB9_HUMANTAP1_HUMANIntAct15488952 details
PSB9_HUMANTAP2_HUMANIntAct15488952 details
PSB9_HUMANGRIP1_HUMANMINT16957778 details
PSB9_HUMANNCOA3_HUMANBioGRID, HPRD, MINT16957778 details
PSB9_HUMANNCOA1_HUMANHPRD, MINT16957778 details
PSB9_HUMANLAGE3_HUMANBioGRID, IntAct32296183 details
PSB9_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
PSB9_HUMANPSA7_HUMANBioGRID, IntAct17506986 17948026 26186194 26344197 28514442 30833792 details
PSB9_HUMANPSA1_HUMANBioGRID, IntAct17948026 26186194 28514442 30833792 8206875 details
PSB9_HUMANSRC_HUMANBioGRID16957778 details
PSB9_HUMANPSB8_HUMANBioGRID17506986 17948026 details
PSB9_HUMANNCOA2_HUMANBioGRID, HPRD16957778 details
PSB9_HUMANCRGA_HUMANBioGRID32296183 details
PSB9_HUMANPSA2_HUMANBioGRID, IntAct15887188 19193609 20937868 26186194 28514442 30833792 details
PSB9_HUMANESR1_HUMANBioGRID, MINT16957778 details
PSB9_HUMANPSME2_HUMANBioGRID, IntAct11745344 26186194 28514442 30833792 details
PSB9_HUMANPSME1_HUMANBioGRID, IntAct11745344 26186194 28514442 30833792 details
PSB9_HUMANPRS8_HUMANBioGRID, IntAct16957778 26186194 28514442 30833792 details
PSB9_HUMANPSB5_HUMANBioGRID, IntAct10816564 22939629 26186194 28514442 30833792 details
PSB9_HUMANPSA4_HUMANBioGRID, IntAct26186194 28514442 30833792 9311996 details
PSB9_HUMANPSA3_HUMANBioGRID, IntAct11139393 26186194 28514442 30833792 details
PSB9_HUMANRPB1_HUMANBioGRID16957778 details
PSB9_HUMANPSB9_HUMANBioGRID11602734 details
PSB9_HUMANPSB6_HUMANBioGRID11745344 details
PSB9_HUMANRPB2_HUMANBioGRID16957778 details
PSB9_HUMANRPB3_HUMANBioGRID16957778 details
PSB9_HUMANRPB4_HUMANBioGRID16957778 details
PSB9_HUMANRPAB1_HUMANBioGRID16957778 details
PSB9_HUMANRPAB2_HUMANBioGRID16957778 details
PSB9_HUMANRPB7_HUMANBioGRID16957778 details
PSB9_HUMANRPAB3_HUMANBioGRID16957778 details
PSB9_HUMANRPB9_HUMANBioGRID16957778 details
PSB9_HUMANRPAB5_HUMANBioGRID16957778 details
PSB9_HUMANRPB11_HUMANBioGRID16957778 details
PSB9_HUMANRPAB4_HUMANBioGRID16957778 details
PSB9_HUMANELOA1_HUMANBioGRID16957778 details
PSB9_HUMANPSB10_HUMANBioGRID, HPRD10329130 26186194 details