Entity Details

Primary name DPOD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28340
EntryNameDPOD1_HUMAN
FullNameDNA polymerase delta catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length1107
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesPOLD1

GO terms

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GOName
GO:0000109 nucleotide-excision repair complex
GO:0000166 nucleotide binding
GO:0000723 telomere maintenance
GO:0000731 DNA synthesis involved in DNA repair
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006298 mismatch repair
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0009411 response to UV
GO:0016020 membrane
GO:0016235 aggresome
GO:0019985 translesion synthesis
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034644 cellular response to UV
GO:0042769 DNA damage response, detection of DNA damage
GO:0043625 delta DNA polymerase complex
GO:0045004 DNA replication proofreading
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0055089 fatty acid homeostasis
GO:0070987 error-free translesion synthesis
GO:0071897 DNA biosynthetic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006133 DNA-directed DNA polymerase, family B, exonuclease domainDomainDomain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domainDomainDomain
IPR006172 DNA-directed DNA polymerase, family BFamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR017964 DNA-directed DNA polymerase, family B, conserved siteSiteConserved site
IPR023211 DNA polymerase, palm domain superfamilyFamilyHomologous superfamily
IPR025687 C4-type zinc-finger of DNA polymerase deltaDomainDomain
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR042087 DNA polymerase family B, thumb domainFamilyHomologous superfamily
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615381 OMIMMandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL)An autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, metabolic abnormalities including insulin resistance and diabetes mellitus, sclerodermatous skin, and a facial appearance characterized by mandibular hypoplasia. Sensorineural deafness occurs late in the first or second decades of life. The disease is caused by variants affecting the gene represented in this entry.
612591 OMIMColorectal cancer 10 (CRCS10)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

58 interactions

InteractorPartnerSourcesPublicationsLink
DPOD1_HUMANSCG1_HUMANBioGRID, HPRD, IntAct16169070 details
DPOD1_HUMANCE126_HUMANBioGRID, HPRD, IntAct16169070 details
DPOD1_HUMANDPOD2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt12403614 16510448 26344197 26496610 27684187 28514442 31449058 9286699 details
DPOD1_HUMANDPOD4_HUMANBioGRID, IntAct, MINT, UniProt12403614 16510448 26496610 31449058 details
DPOD1_HUMANPCNA_HUMANBioGRID, HPRD, IntAct, UniProt11328591 12171929 12403614 14988403 15805117 16510448 20227374 24768535 24958773 26496610 details
DPOD1_HUMANABL1_HUMANIntAct17474147 details
DPOD1_HUMANSRC_HUMANIntAct17474147 details
DPOD1_HUMANFYN_HUMANIntAct17474147 details
DPOD1_HUMANGRB2_HUMANIntAct17474147 details
DPOD1_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 34079125 details
DPOD1_HUMANKLH12_HUMANIntAct32296183 details
DPOD1_HUMANCRTP1_HUMANIntAct32296183 details
DPOD1_HUMANATL4_HUMANBioGRID, IntAct32296183 details
DPOD1_HUMANLASP1_HUMANBioGRID, IntAct32296183 details
DPOD1_HUMANATR_HUMANBioGRID10608806 details
DPOD1_HUMANSLD5_HUMANBioGRID21705323 details
DPOD1_HUMANCDK4_HUMANBioGRID9545286 details
DPOD1_HUMANCCND3_HUMANBioGRID9545286 details
DPOD1_HUMANCDK2_HUMANBioGRID, HPRD9545286 details
DPOD1_HUMANCCNE1_HUMANBioGRID9545286 details
DPOD1_HUMANMCPH1_HUMANBioGRID29150431 details
DPOD1_HUMANRB_HUMANBioGRID11114723 details
DPOD1_HUMANYPEL3_HUMANBioGRID32296183 details
DPOD1_HUMANTRI55_HUMANBioGRID31391242 details
DPOD1_HUMANSUMO2_HUMANBioGRID32786267 details
DPOD1_HUMANDPOD3_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10852724 11328591 12403614 16510448 26496610 27684187 31449058 details
DPOD1_HUMANGBRL2_HUMANIntAct17353931 details
DPOD1_HUMANARF6_HUMANIntAct17353931 details
DPOD1_HUMANMAGA6_HUMANIntAct17353931 details
DPOD1_HUMANGSTK1_HUMANIntAct17353931 details
DPOD1_HUMANWRIP1_HUMANBioGRID, HPRD, UniProt15670210 details
DPOD1_HUMANDDX20_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANE2AK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANRBM14_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANEAF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANNAF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANNOLC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANMFAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANATRX_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANAP3B1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DPOD1_HUMANMMS19_HUMANBioGRID, IntAct22678361 22678362 28178521 details
DPOD1_HUMANCIA2B_HUMANBioGRID, IntAct23891004 28178521 details
DPOD1_HUMANCND3_HUMANBioGRID16543152 details
DPOD1_HUMANRENT1_HUMANBioGRID16488880 details
DPOD1_HUMANRENT2_HUMANBioGRID16488880 details
DPOD1_HUMANMGMT_HUMANBioGRID16226712 details
DPOD1_HUMANTERF2_HUMANBioGRID20811636 details
DPOD1_HUMANERPG3_HUMANBioGRID20541997 details
DPOD1_HUMANERCC6_HUMANBioGRID20541997 details
DPOD1_HUMANXRCC1_HUMANBioGRID20227374 details
DPOD1_HUMANPOLK_HUMANBioGRID20227374 details
DPOD1_HUMANDHX9_HUMANBioGRID15995249 details
DPOD1_HUMANSPRTN_HUMANBioGRID23254330 27871366 details
DPOD1_HUMANRN126_HUMANBioGRID26508657 details
DPOD1_HUMANRAD51_HUMANBioGRID28757209 details
DPOD1_HUMANUBR5_HUMANBioGRID31586398 details
DPOD1_HUMANHAUS7_HUMANHPRD12806015 details
DPOD1_HUMANXRCC5_HUMANHPRD12393188 details