Entity Details

Primary name DUS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28562
EntryNameDUS1_HUMAN
FullNameDual specificity protein phosphatase 1
TaxID9606
Evidenceevidence at protein level
Length367
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesDUSP1

GO terms

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GOName
GO:0000188 obsolete inactivation of MAPK activity
GO:0001706 endoderm formation
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006470 protein dephosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0009416 response to light stimulus
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0019838 growth factor binding
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032870 cellular response to hormone stimulus
GO:0033574 response to testosterone
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0051019 mitogen-activated protein kinase binding
GO:0051384 response to glucocorticoid
GO:0051447 negative regulation of meiotic cell cycle
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0070262 peptidyl-serine dephosphorylation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090027 negative regulation of monocyte chemotaxis
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903753 negative regulation of p38MAPK cascade
GO:1990869 cellular response to chemokine
GO:2000279 negative regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR008343 Mitogen-activated protein (MAP) kinase phosphataseFamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
DUS1_HUMANMK01_HUMANBioGRID, HPRD, IntAct10617468 11278799 16286470 18519678 27432908 31980649 details
DUS1_HUMANUBB_HUMANHPRD, IntAct16286470 details
DUS1_HUMANMK14_HUMANBioGRID, HPRD, IntAct, MINT11278799 11359773 20347885 20936779 25241761 27432908 27880917 28675297 7535770 details
DUS1_HUMANRPA12_HUMANBioGRID, IntAct21988832 details
DUS1_HUMANMK03_HUMANBioGRID, HPRD, IntAct, MINT10617468 11278799 20347885 25241761 31980649 details
DUS1_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
DUS1_HUMANLMTK1_HUMANBioGRID, MINT28065597 details
DUS1_HUMANROR2_HUMANBioGRID, MINT28065597 details
DUS1_HUMANMK08_HUMANBioGRID, HPRD11278799 28675297 details
DUS1_HUMANTAU_HUMANBioGRID7616230 details
DUS1_HUMANAMFR_HUMANBioGRID31061093 details
DUS1_HUMANSKP2_HUMANBioGRID, HPRD, IntAct16286470 18519678 details
DUS1_HUMANCKS1_HUMANBioGRID, HPRD, IntAct16286470 18519678 details
DUS1_HUMANMK12_HUMANBioGRID, HPRD, IntAct11062068 25241761 details
DUS1_HUMANMK09_HUMANBioGRID11359773 28675297 details
DUS1_HUMANMK10_HUMANBioGRID11359773 details
DUS1_HUMANIKKA_HUMANBioGRID10022904 details
DUS1_HUMANIKKB_HUMANBioGRID10022904 details
DUS1_HUMANKPCI_HUMANBioGRID10022904 details
DUS1_HUMANFBX32_HUMANBioGRID19117950 details
DUS1_HUMANHSP74_HUMANBioGRID, HPRD15677475 details
DUS1_HUMANUBP49_HUMANBioGRID30246457 details
DUS1_HUMANNF2L2_HUMANBioGRID31811110 details
DUS1_HUMANUBP33_HUMANBioGRID31857702 details
DUS1_HUMANTRI46_HUMANBioGRID31918570 details