Entity Details

Primary name NEC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29120
EntryNameNEC1_HUMAN
FullNameNeuroendocrine convertase 1
TaxID9606
Evidenceevidence at protein level
Length753
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesPCSK1

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0016020 membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0030133 transport vesicle
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043043 peptide biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000209 Peptidase S8/S53 domainDomainDomain
IPR002884 P domainDomainDomain
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR015500 Peptidase S8, subtilisin-relatedFamilyFamily
IPR022005 Prohormone convertase enzymeDomainDomain
IPR022398 Peptidase S8, subtilisin, His-active siteSiteActive site
IPR023827 Peptidase S8, subtilisin, Asp-active siteSiteActive site
IPR023828 Peptidase S8, subtilisin, Ser-active siteSiteActive site
IPR032815 Peptidase S8, pro-domainDomainDomain
IPR034182 Kexin/furin catalytic domainDomainDomain
IPR036852 Peptidase S8/S53 domain superfamilyFamilyHomologous superfamily
IPR038466 Peptidase S8, pro-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech