Entity Details

Primary name SHC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29353
EntryNameSHC1_HUMAN
FullNameSHC-transforming protein 1
TaxID9606
Evidenceevidence at protein level
Length583
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesSHC1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005543 phospholipid binding
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030971 receptor tyrosine kinase binding
GO:0031532 actin cytoskeleton reorganization
GO:0035723 interleukin-15-mediated signaling pathway
GO:0036498 IRE1-mediated unfolded protein response
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0040008 regulation of growth
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046875 ephrin receptor binding
GO:0048408 epidermal growth factor binding
GO:0050900 leukocyte migration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070435 Shc-EGFR complex
GO:0071363 cellular response to growth factor stimulus
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090322 regulation of superoxide metabolic process
GO:0098609 cell-cell adhesion

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR006019 Phosphotyrosine interaction domain, Shc-likeDomainDomain
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR029586 SHC-transforming protein 1FamilyFamily
IPR035676 SH2 adaptor protein C, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

166 interactions

InteractorPartnerSourcesPublicationsLink
SHC1_HUMANLYN_HUMANBioGRID, HPRD, MINT7516469 7650013 details
SHC1_HUMANFYN_HUMANHPRD, MINT10482988 10764799 10816433 10896916 10921922 11075717 12237775 7516469 9121430 9446569 9710204 9741627 details
SHC1_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT16135792 16219545 19380743 19889638 23397142 7537361 8621719 8662998 9541596 details
SHC1_HUMANEGFR_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10049786 10595738 10635327 10766863 11196191 11370743 11408594 12577067 15657067 16273093 16729043 18271526 19531499 20067773 20473329 20935677 21278788 22973453 23178716 23799367 23956138 24189400 24430869 24658140 24797263 25187647 25402006 25754235 26551075 28065597 30544639 31585087 31959764 31980649 7506413 7518560 7542744 7542991 8034616 8610109 8662998 8665853 8810340 8887653 9020193 9130710 9388490 9544989 9756944 details
SHC1_HUMANFCGR1_HUMANMINT9716598 details
SHC1_HUMANGAB2_HUMANBioGRID, HPRD, MINT10704825 11782427 12135708 14982882 details
SHC1_HUMANSHIP1_HUMANBioGRID, HPRD, MINT10194451 10704825 10822173 10900203 11453982 12024011 12149229 15470047 8643691 8723348 8874179 details
SHC1_HUMANDDR2_HUMANBioGRID, HPRD, MINT11884411 details
SHC1_HUMANA4_HUMANBioGRID, HPRD, IntAct, MINT11877420 12485888 9045663 details
SHC1_HUMANGRB2_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10049786 10080542 10356320 10477741 10570290 11302736 11370743 11453982 11505033 11707405 11792427 11827484 11964172 12149229 12213123 12441060 12485888 12577067 12898421 15688026 15812354 15888547 16371368 16520382 19380743 21706016 21725358 22057045 22974441 23178716 24189400 24430869 25416956 26551075 28690151 31980649 32062451 7514169 7516467 7524086 7535773 7537740 7559490 7597091 7629070 7650032 7744881 7798267 8112292 8195171 8235613 8294403 8491186 8561895 8621719 8626525 8647288 8662733 8662998 8663178 8810340 8939605 8940013 8950973 8995379 9019162 9020193 9032244 9045692 9083103 9126968 9129019 9175774 9254595 9434624 9488479 9541596 9544989 9733714 9797459 9886492 9927207 details
SHC1_HUMANCADH5_HUMANBioGRID, HPRD, MINT11950700 details
SHC1_HUMANVGFR2_HUMANBioGRID, HPRD, MINT10319320 10749680 11950700 12214271 details
SHC1_HUMANIGF1R_HUMANBioGRID, IntAct14764897 15629149 16113100 24051437 7541045 7559507 8776723 details
SHC1_HUMANINSR_HUMANBioGRID, HPRD, IntAct, MINT10482988 10764799 10803466 10816433 10896916 10921922 11075717 12237775 15629149 7499194 8702728 9083103 9121430 9446569 9593725 9710204 9741627 details
SHC1_HUMANRET_HUMANBioGRID, HPRD, MINT15677445 28213521 32062451 8183561 9047384 details
SHC1_HUMANZAP70_HUMANBioGRID, HPRD, MINT15688026 23267066 7961936 8235613 8761298 9685404 details
SHC1_HUMANERBB2_HUMANBioGRID, HPRD, IntAct, MINT10085134 16273093 16729043 16843263 22973453 24658140 28065597 30898150 8665853 9019162 9710588 9756944 details
SHC1_HUMANERBB3_HUMANBioGRID, HPRD, IntAct, MINT11546794 16273093 16729043 22973453 24189400 24658140 8665853 9019162 9694850 9756944 details
SHC1_HUMANERBB4_HUMANBioGRID, HPRD, IntAct, MINT16273093 16729043 22973453 24658140 9019162 details
SHC1_HUMANCACO2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
SHC1_HUMANUBS3B_HUMANBioGRID, IntAct19380743 24189400 28690151 details
SHC1_HUMANCSK_HUMANBioGRID, HPRD, IntAct10037694 12048194 19380743 details
SHC1_HUMANPTN12_HUMANBioGRID, HPRD, IntAct, MINT11342545 11432829 12052829 19380743 24189400 24412244 27880917 28514442 28675297 31980649 7929214 8626541 details
SHC1_HUMANAP2A2_HUMANBioGRID, HPRD, IntAct19380743 24189400 31980649 8617812 details
SHC1_HUMANKPCD_HUMANBioGRID, HPRD, IntAct12024011 19380743 31980649 details
SHC1_HUMANTIE2_HUMANBioGRID, HPRD, MINT14665640 details
SHC1_HUMANNTRK1_HUMANBioGRID, HPRD, MINT10092678 10629055 10708759 12446789 25921289 28213521 29715200 7541035 8155326 8183561 8226808 9856458 details
SHC1_HUMANESR1_HUMANBioGRID, HPRD, I2D11773443 20935677 details
SHC1_HUMANSMAP_HUMANBioGRID, MINT21900206 details
SHC1_HUMANCBLC_HUMANBioGRID, MINT21900206 details
SHC1_HUMANDUS23_HUMANBioGRID, MINT21900206 details
SHC1_HUMANF118B_HUMANBioGRID, MINT21900206 details
SHC1_HUMANGEMI7_HUMANBioGRID, MINT21900206 details
SHC1_HUMANHMOX2_HUMANBioGRID, MINT21900206 details
SHC1_HUMANILK_HUMANBioGRID, MINT21900206 details
SHC1_HUMANMK06_HUMANBioGRID, MINT21900206 details
SHC1_HUMANRM44_HUMANBioGRID, MINT21900206 details
SHC1_HUMANCPSF5_HUMANBioGRID, MINT21900206 details
SHC1_HUMANOSGEP_HUMANBioGRID, MINT21900206 details
SHC1_HUMANPRKRA_HUMANBioGRID, MINT21900206 details
SHC1_HUMANSUV92_HUMANBioGRID, MINT21900206 details
SHC1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
SHC1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
SHC1_HUMANRB_HUMANBioGRID, MINT24412244 details
SHC1_HUMANSMAD4_HUMANBioGRID, MINT24412244 details
SHC1_HUMANANDR_HUMANBioGRID, IntAct24728074 details
SHC1_HUMANGAB1_HUMANBioGRID, HPRD, IntAct12808090 14982882 24728074 9804835 details
SHC1_HUMANKIT_HUMANBioGRID, IntAct24728074 details
SHC1_HUMANMET_HUMANBioGRID, HPRD, IntAct24728074 7731718 9660480 details
SHC1_HUMANMK01_HUMANBioGRID, DIP, HPRD10996427 23584453 details
SHC1_HUMANSRC_HUMANBioGRID, DIP, HPRD10482988 18840094 26551075 7499252 8939605 9096689 9388490 9710204 details
SHC1_HUMANDDR1_HUMANBioGRID, HPRD, MINT10783152 22057045 9659899 details
SHC1_HUMANPTPRA_HUMANMINT28065597 details
SHC1_HUMANSERB_HUMANBioGRID, IntAct26344197 31515488 details
SHC1_HUMANKCC2A_HUMANIntAct32814053 details
SHC1_HUMANKSYK_HUMANHPRD, IntAct10482988 32814053 9096689 9388490 9710204 details
SHC1_HUMANVGFR1_HUMANBioGRID, HPRD10749680 details
SHC1_HUMANMAPK2_HUMANBioGRID, HPRD15094067 details
SHC1_HUMANDOK1_HUMANBioGRID, HPRD10822173 11071635 22974441 details
SHC1_HUMANPLS1_HUMANBioGRID, HPRD12009895 12871937 details
SHC1_HUMANLRP1_HUMANBioGRID, HPRD11854294 12069755 12789267 details
SHC1_HUMANIL2RB_HUMANBioGRID, HPRD10602027 8294403 details
SHC1_HUMANIL4RA_HUMANBioGRID, HPRD10652211 11714803 details
SHC1_HUMANITB4_HUMANBioGRID, HPRD11044453 details
SHC1_HUMANEPHA2_HUMANBioGRID, HPRD12400011 details
SHC1_HUMANCSF3R_HUMANBioGRID, HPRD14557262 17001306 9824671 details
SHC1_HUMANVGFR3_HUMANBioGRID, HPRD7675451 7970715 8662748 9927207 details
SHC1_HUMANSHCBP_HUMANBioGRID, HPRD10086341 details
SHC1_HUMANDAG1_HUMANBioGRID, HPRD11724572 details
SHC1_HUMANPHAG1_HUMANBioGRID, HPRD10790433 details
SHC1_HUMANNTRK2_HUMANBioGRID, HPRD10092678 12419535 16034442 26253177 28213521 details
SHC1_HUMANNTRK3_HUMANBioGRID, HPRD10092678 7657612 details
SHC1_HUMANEPS8_HUMANBioGRID, HPRD7791787 details
SHC1_HUMANSOMA_HUMANBioGRID7535773 details
SHC1_HUMANJAK2_HUMANBioGRID, HPRD7535773 9126968 details
SHC1_HUMANGHR_HUMANBioGRID, HPRD7535773 9632636 details
SHC1_HUMANP3C2B_HUMANBioGRID11533253 details
SHC1_HUMANIL6RB_HUMANBioGRID9126968 details
SHC1_HUMANSH2B2_HUMANBioGRID, HPRD9233773 details
SHC1_HUMANTRI15_HUMANBioGRID25450970 details
SHC1_HUMANITB3_HUMANBioGRID, HPRD10896934 10964917 19889638 details
SHC1_HUMANFGFR1_HUMANBioGRID, HPRD18022941 7514169 7559490 details
SHC1_HUMANFGFR2_HUMANBioGRID18840094 details
SHC1_HUMANPTN11_HUMANBioGRID, HPRD10650943 11453982 details
SHC1_HUMANPTN2_HUMANBioGRID, HPRD15588985 9488479 details
SHC1_HUMANGRB7_HUMANBioGRID, HPRD7907978 8940081 details
SHC1_HUMAN1433Z_HUMANMINT11342545 19218246 details
SHC1_HUMANCEAM1_HUMANBioGRID, HPRD, MINT11694516 details
SHC1_HUMANCBL_HUMANBioGRID, HPRD, IntAct, MINT10025673 10570290 15677445 19380743 8621719 8662998 8950973 9234717 9434624 9461587 9541596 details
SHC1_HUMANLCP2_HUMANBioGRID, HPRD, MINT9716598 details
SHC1_HUMANIL3RB_HUMANBioGRID, HPRD, MINT10477722 10704825 15194700 16437163 details
SHC1_HUMANK1C18_HUMANHPRD, IntAct12577067 details
SHC1_HUMANSOS1_HUMANBioGRID, HPRD, IntAct, MINT10025673 10570290 10675333 10783152 16371368 19380743 7520523 7559490 8235613 8621459 8626525 8631299 8950973 9344843 9544989 details
SHC1_HUMANSHIP2_HUMANBioGRID, HPRD, IntAct10194451 11349134 19380743 9660833 details
SHC1_HUMANP85B_HUMANBioGRID, HPRD, IntAct19380743 8662998 details
SHC1_HUMANCRK_HUMANBioGRID, HPRD, IntAct10464310 19380743 23397142 8035825 9461587 9617486 9837978 details
SHC1_HUMANAP2A1_HUMANBioGRID, HPRD, IntAct11302736 19380743 24189400 28514442 31980649 8617812 details
SHC1_HUMANSHC1_HUMANBioGRID, IntAct, MINT19380743 22057045 24189400 31980649 8561895 details
SHC1_HUMANIQGA1_HUMANBioGRID, MINT19380743 20075861 details
SHC1_HUMANFCG2B_HUMANBioGRID, MINT10382761 8940017 details
SHC1_HUMANTGFR2_HUMANMINT17440088 details
SHC1_HUMANCD3E_HUMANHPRD, MINT11855827 details
SHC1_HUMANCD3Z_HUMANBioGRID, HPRD, MINT7544002 8647168 8656061 details
SHC1_HUMANGRAP_HUMANHPRD, MINT8995379 details
SHC1_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct10996427 23397142 details
SHC1_HUMANLRRK1_HUMANBioGRID, IntAct20697350 24947832 31980649 details
SHC1_HUMANDOK2_HUMANBioGRID10822173 details
SHC1_HUMANABL1_HUMANBioGRID10194451 19380743 8112292 details
SHC1_HUMANCD22_HUMANBioGRID, HPRD10748054 details
SHC1_HUMANPLCG2_HUMANBioGRID, HPRD10623845 12135708 details
SHC1_HUMANFAK1_HUMANBioGRID11980671 details
SHC1_HUMANPLCG1_HUMANBioGRID, HPRD10652211 8155326 8662733 details
SHC1_HUMANCBLB_HUMANBioGRID, HPRD9614102 details
SHC1_HUMANALK_HUMANBioGRID, HPRD11888936 9174053 details
SHC1_HUMANSOS2_HUMANBioGRID, HPRD10675333 19380743 details
SHC1_HUMANIL2RG_HUMANBioGRID, HPRD8643566 details
SHC1_HUMANEPOR_HUMANBioGRID, HPRD8400282 details
SHC1_HUMANVAV3_HUMANBioGRID, HPRD11094073 details
SHC1_HUMANTNR16_HUMANBioGRID, HPRD7541035 details
SHC1_HUMANPGFRB_HUMANBioGRID, HPRD8195171 details
SHC1_HUMANCRKL_HUMANBioGRID, HPRD9344843 details
SHC1_HUMANRPGF1_HUMANBioGRID, HPRD9344843 details
SHC1_HUMANSTA5B_HUMANBioGRID, HPRD10996427 details
SHC1_HUMANCALD1_HUMANBioGRID, HPRD10559276 details
SHC1_HUMANRON_HUMANBioGRID, HPRD8918464 details
SHC1_HUMANHIF1A_HUMANBioGRID12114320 details
SHC1_HUMANCSF1R_HUMANBioGRID, HPRD10025673 7520523 details
SHC1_HUMANBCR_HUMANBioGRID, HPRD19380743 9209414 details
SHC1_HUMANTEC_HUMANBioGRID, HPRD11825908 19380743 details
SHC1_HUMANRHG32_HUMANBioGRID12446789 details
SHC1_HUMANITAV_HUMANBioGRID19889638 details
SHC1_HUMANITB1_HUMANBioGRID19889638 details
SHC1_HUMANLTK_HUMANBioGRID, HPRD7650032 9223670 details
SHC1_HUMANCD81_HUMANBioGRID, HPRD14676841 30024968 details
SHC1_HUMANSHPS1_HUMANBioGRID15888547 details
SHC1_HUMANEGF_HUMANBioGRID9020193 details
SHC1_HUMANMLP3A_HUMANBioGRID30109811 details
SHC1_HUMANAAPK1_HUMANBioGRID30109811 details
SHC1_HUMANYES_HUMANBioGRID7499252 details
SHC1_HUMANCD3G_HUMANBioGRID8647168 details
SHC1_HUMANCD3D_HUMANBioGRID8647168 details
SHC1_HUMANFCG3A_HUMANBioGRID, HPRD8235613 9378963 details
SHC1_HUMANSP1_HUMANHPRD7933095 details
SHC1_HUMANBCL3_HUMANHPRD11707390 details
SHC1_HUMANIRS2_HUMANHPRD11505033 details
SHC1_HUMANFAK2_HUMANHPRD7544443 details
SHC1_HUMAN2A5A_HUMANHPRD11884620 details
SHC1_HUMANM4K1_HUMANHPRD9346925 details
SHC1_HUMANGRAP2_HUMANHPRD9872323 details
SHC1_HUMANTPR_HUMANHPRD11896612 details
SHC1_HUMANUFO_HUMANHPRD8610109 details
SHC1_HUMANNPM_HUMANHPRD8633037 details
SHC1_HUMANKPCA_HUMANHPRD12052829 details
SHC1_HUMANNEP_HUMANHPRD9659899 details
SHC1_HUMANRASA1_HUMANHPRD8155326 details
SHC1_HUMANTPOR_HUMANHPRD10224114 9122198 details
SHC1_HUMANPTN6_HUMANHPRD8541543 details
SHC1_HUMANPLPP3_HUMANHPRD16099422 details
SHC1_HUMANVAV_HUMANHPRD15688026 details
SHC1_HUMANPAK1_HUMANHPRD15688026 details
SHC1_HUMANMK14_HUMANHPRD15688026 details
SHC1_HUMANMK08_HUMANHPRD15688026 details
SHC1_HUMANFCG2A_HUMANHPRD10382761 8940017 details
SHC1_HUMANIRS1_HUMANHPRD7499194 details
SHC1_HUMANIL2_HUMANHPRD10662798 details
SHC1_HUMANLCK_HUMANHPRD10482988 10764799 10816433 10896916 10921922 11075717 12237775 9121430 9446569 9710204 9741627 details