Entity Details

Primary name AA1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30542
EntryNameAA1R_HUMAN
FullNameAdenosine receptor A1
TaxID9606
Evidenceevidence at protein level
Length326
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesADORA1

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001609 G protein-coupled adenosine receptor activity
GO:0001659 temperature homeostasis
GO:0001664 G protein-coupled receptor binding
GO:0001666 response to hypoxia
GO:0001883 purine nucleoside binding
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0002674 negative regulation of acute inflammatory response
GO:0002686 negative regulation of leukocyte migration
GO:0002793 positive regulation of peptide secretion
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003093 regulation of glomerular filtration
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006612 protein targeting to membrane
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0008285 negative regulation of cell population proliferation
GO:0014050 negative regulation of glutamate secretion
GO:0014069 postsynaptic density
GO:0016042 lipid catabolic process
GO:0016323 basolateral plasma membrane
GO:0030673 axolemma
GO:0031072 heat shock protein binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0032244 positive regulation of nucleoside transport
GO:0032795 heterotrimeric G-protein binding
GO:0032900 negative regulation of neurotrophin production
GO:0035307 positive regulation of protein dephosphorylation
GO:0035814 negative regulation of renal sodium excretion
GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043268 positive regulation of potassium ion transport
GO:0044305 calyx of Held
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045822 negative regulation of heart contraction
GO:0046888 negative regulation of hormone secretion
GO:0046982 protein heterodimerization activity
GO:0048786 presynaptic active zone
GO:0050890 cognition
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050995 negative regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0051930 regulation of sensory perception of pain
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0055089 fatty acid homeostasis
GO:0060079 excitatory postsynaptic potential
GO:0060087 relaxation of vascular associated smooth muscle
GO:0070256 negative regulation of mucus secretion
GO:0070328 triglyceride homeostasis
GO:0086004 regulation of cardiac muscle cell contraction
GO:0097190 apoptotic signaling pathway
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099582 neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900453 negative regulation of long-term synaptic depression
GO:1901216 positive regulation of neuron death

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001068 Adenosine A1 receptorFamilyFamily
IPR001634 Adenosine receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00193 TramadolDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00640 AdenosineDrugbanksmall molecule
DB00651 DyphyllineDrugbanksmall molecule
DB00806 PentoxifyllineDrugbanksmall molecule
DB00824 EnprofyllineDrugbanksmall molecule
DB00996 GabapentinDrugbanksmall molecule
DB01223 AminophyllineDrugbanksmall molecule
DB01303 OxtriphyllineDrugbanksmall molecule
DB01412 TheobromineDrugbanksmall molecule
DB04932 DefibrotideDrugbankbiotech
DB04954 TecadenosonDrugbanksmall molecule
DB06471 NaxifyllineDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB12569 TonapofyllineDrugbanksmall molecule
DB12670 RolofyllineDrugbanksmall molecule