Entity Details

Primary name ACSL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33121
EntryNameACSL1_HUMAN
FullNameLong-chain-fatty-acid--CoA ligase 1
TaxID9606
Evidenceevidence at protein level
Length698
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesACSL1

GO terms

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GOName
GO:0000038 very long-chain fatty acid metabolic process
GO:0001676 long-chain fatty acid metabolic process
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0007584 response to nutrient
GO:0008610 lipid biosynthetic process
GO:0010747 positive regulation of long-chain fatty acid import across plasma membrane
GO:0014070 response to organic cyclic compound
GO:0015908 fatty acid transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019222 regulation of metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0033211 adiponectin-activated signaling pathway
GO:0034201 response to oleic acid
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0042178 xenobiotic catabolic process
GO:0042493 response to drug
GO:0043651 linoleic acid metabolic process
GO:0044539 long-chain fatty acid import into cell
GO:0047676 arachidonate-CoA ligase activity
GO:0050197 phytanate-CoA ligase activity
GO:0070251 pristanate-CoA ligase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090434 oleoyl-CoA ligase activity
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion outer membrane
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR000873 AMP-dependent synthetase/ligaseDomainDomain
IPR020845 AMP-binding, conserved siteSiteConserved site
IPR025110 AMP-binding enzyme, C-terminal domainDomainDomain
IPR042099 ANL, N-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule

Interactions

4 interactions