Entity Details

Primary name CTNA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35221
EntryNameCTNA1_HUMAN
FullNameCatenin alpha-1
TaxID9606
Evidenceevidence at protein level
Length906
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesCTNNA1

GO terms

Show/Hide Table
GOName
GO:0001541 ovarian follicle development
GO:0001669 acrosomal vesicle
GO:0003723 RNA binding
GO:0005198 structural molecule activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005915 zonula adherens
GO:0005925 focal adhesion
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007406 negative regulation of neuroblast proliferation
GO:0007568 aging
GO:0008013 beta-catenin binding
GO:0008584 male gonad development
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016264 gap junction assembly
GO:0016342 catenin complex
GO:0016477 cell migration
GO:0016600 flotillin complex
GO:0017166 vinculin binding
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031103 axon regeneration
GO:0034332 adherens junction organization
GO:0034613 cellular protein localization
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043297 apical junction assembly
GO:0043627 response to estrogen
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0045880 positive regulation of smoothened signaling pathway
GO:0051015 actin filament binding
GO:0051149 positive regulation of muscle cell differentiation
GO:0071681 cellular response to indole-3-methanol
GO:0090136 epithelial cell-cell adhesion
GO:0098609 cell-cell adhesion
GO:1900181 negative regulation of protein localization to nucleus
GO:2000146 negative regulation of cell motility
GO:2001045 negative regulation of integrin-mediated signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000633 Vinculin, conserved siteSiteConserved site
IPR001033 Alpha-cateninFamilyFamily
IPR006077 Vinculin/alpha-cateninFamilyFamily
IPR030047 Alpha E-catenin/Alpha T-cateninFamilyFamily
IPR036723 Alpha-catenin/vinculin-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
608970 OMIMMacular dystrophy, patterned, 2 (MDPT2)A form of retinal patterned dystrophy, a heterogeneous group of macular disorders caused by abnormal accumulation of lipofuscin in the retinal pigment epithelium. Lipofuscin distribution can show various shapes that define different types of macular dystrophy, including reticular (fishnet-like) dystrophy, macroreticular (spider-shaped) dystrophy and butterfly-shaped pigment dystrophy. MDPT2 is an autosomal dominant form characterized by bilateral accumulation of pigment in the macular area that resembles the wings of a butterfly. The disease is caused by variants affecting the gene represented in this entry.

Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
CTNA1_HUMANCTNB1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12640114 14517306 15492215 17052462 17072306 17098867 19941816 24509793 26344197 26496610 27684187 34079125 7706414 7954478 9110993 9512503 9762469 details
CTNA1_HUMANAPC_HUMANBioGRID, IntAct20936779 25241761 26496610 29045831 34079125 7651399 8259519 details
CTNA1_HUMANOBI1_HUMANBioGRID, IntAct20936779 details
CTNA1_HUMANPLAK_HUMANBioGRID, HPRD, IntAct14517306 20936779 22939629 25241761 26344197 34079125 7650039 7890674 9110993 9762469 details
CTNA1_HUMANZGPAT_HUMANBioGRID, IntAct20936779 details
CTNA1_HUMANCTBP1_HUMANBioGRID, MINT21900206 details
CTNA1_HUMANAFAD_HUMANBioGRID, IntAct11907041 23750010 34079125 details
CTNA1_HUMANAKT1_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANBAAT_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANALDOB_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANCATL2_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANF16P1_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANF16P2_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANFRAT2_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANRASH_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANDHB3_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANCC180_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANSIAS_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANSFRP2_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANSTX17_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANTDRD7_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANZN189_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANZN510_HUMANBioGRID, MINT24412244 details
CTNA1_HUMANVINC_HUMANBioGRID, DIP, HPRD, IntAct23292143 26496610 34079125 9700171 details
CTNA1_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
CTNA1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
CTNA1_HUMANCTNA1_HUMANBioGRID, DIP23292143 9762469 details
CTNA1_HUMANCE350_HUMANBioGRID, DIP25764135 34079125 details
CTNA1_HUMANPAR2_HUMANBioGRID, MINT28298427 details
CTNA1_HUMANARMC8_HUMANBioGRID, IntAct18215130 30482882 details
CTNA1_HUMANZO2_HUMANBioGRID, HPRD10026224 details
CTNA1_HUMANSPTB2_HUMANBioGRID11069925 details
CTNA1_HUMANLRAT2_HUMANBioGRID, HPRD12477722 details
CTNA1_HUMANA4_HUMANBioGRID21244100 21832049 details
CTNA1_HUMANUBC9_HUMANBioGRID15561718 details
CTNA1_HUMANIQEC1_HUMANBioGRID16807291 details
CTNA1_HUMANCSK21_HUMANBioGRID19941816 details
CTNA1_HUMANSASH1_HUMANBioGRID30480076 details
CTNA1_HUMANCDC42_HUMANBioGRID31478661 details
CTNA1_HUMANCADH1_HUMANBioGRID, DIP, IntAct, MINT10381631 11960376 16212417 19016843 22750944 25468996 7542250 8227214 9233779 details
CTNA1_HUMANCADH5_HUMANBioGRID, HPRD, IntAct, MINT12003790 17057644 28514442 9434630 details
CTNA1_HUMANPARD3_HUMANBioGRID, MINT17057644 34079125 details
CTNA1_HUMANACTN1_HUMANBioGRID, HPRD, IntAct25241761 7790378 details
CTNA1_HUMANNEK4_HUMANBioGRID, IntAct27173435 unassigned1312 details
CTNA1_HUMANNHRF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CTNA1_HUMANLIMA1_HUMANDIP18093941 details
CTNA1_HUMANRGAP1_HUMANDIP22750944 details
CTNA1_HUMANECT2_HUMANDIP22750944 details
CTNA1_HUMANIKBA_HUMANDIP24509793 details
CTNA1_HUMANDISC1_HUMANIntAct31413325 details
CTNA1_HUMANCADH3_HUMANBioGRID, HPRD10381631 10910767 1924379 8227214 details
CTNA1_HUMANCTND1_HUMANBioGRID34079125 7651399 details
CTNA1_HUMANCADH2_HUMANBioGRID, HPRD12604612 14625392 22939629 details
CTNA1_HUMANCAH9_HUMANBioGRID, HPRD14567991 details
CTNA1_HUMANPTN14_HUMANBioGRID12808048 details
CTNA1_HUMANVEZA_HUMANBioGRID11080149 details
CTNA1_HUMANMYO7A_HUMANBioGRID11080149 details
CTNA1_HUMANPSN1_HUMANBioGRID, HPRD10635315 details
CTNA1_HUMANDLG1_HUMANBioGRID, HPRD9512503 details
CTNA1_HUMANCTNA3_HUMANBioGRID23718855 details
CTNA1_HUMANCF298_HUMANBioGRID26472760 details
CTNA1_HUMANZO1_HUMANBioGRID, HPRD34079125 9214391 details
CTNA1_HUMANCAD15_HUMANHPRD9168809 details
CTNA1_HUMANSPTN1_HUMANHPRD11069925 details
CTNA1_HUMANPKD1_HUMANHPRD11274246 details
CTNA1_HUMANAJUBA_HUMANHPRD12417594 details