Entity Details

Primary name RADI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35241
EntryNameRADI_HUMAN
FullNameRadixin
TaxID9606
Evidenceevidence at protein level
Length583
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRDX

GO terms

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GOName
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0010628 positive regulation of gene expression
GO:0010737 protein kinase A signaling
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030315 T-tubule
GO:0030335 positive regulation of cell migration
GO:0030496 midbody
GO:0030864 cortical actin cytoskeleton
GO:0032154 cleavage furrow
GO:0032231 regulation of actin filament bundle assembly
GO:0032487 regulation of Rap protein signal transduction
GO:0034111 negative regulation of homotypic cell-cell adhesion
GO:0034260 negative regulation of GTPase activity
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043087 regulation of GTPase activity
GO:0045176 apical protein localization
GO:0045184 establishment of protein localization
GO:0045296 cadherin binding
GO:0045792 negative regulation of cell size
GO:0051016 barbed-end actin filament capping
GO:0051018 protein kinase A binding
GO:0051117 ATPase binding
GO:0051286 cell tip
GO:0061028 establishment of endothelial barrier
GO:0070062 extracellular exosome
GO:0071944 cell periphery
GO:0072659 protein localization to plasma membrane
GO:0097067 cellular response to thyroid hormone stimulus
GO:1900027 regulation of ruffle assembly
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902115 regulation of organelle assembly
GO:1902966 positive regulation of protein localization to early endosome
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903392 negative regulation of adherens junction organization
GO:2000643 positive regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cleavage furrow
Cytoplasm

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Disease IDSourceNameDescription
611022 OMIMDeafness, autosomal recessive, 24 (DFNB24)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03401 1D-myo-inositol 1,4,5-trisphosphateDrugbanksmall molecule