Entity Details

Primary name RFC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35251
EntryNameRFC1_HUMAN
FullNameReplication factor C subunit 1
TaxID9606
Evidenceevidence at protein level
Length1148
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRFC1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006261 DNA-dependent DNA replication
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0007004 telomere maintenance via telomerase
GO:0008047 enzyme activator activity
GO:0019904 protein domain specific binding
GO:0019985 translesion synthesis
GO:0031391 Elg1 RFC-like complex
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0042276 error-prone translesion synthesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0061860 DNA clamp unloader activity
GO:0070062 extracellular exosome
GO:0070987 error-free translesion synthesis
GO:0090618 DNA clamp unloading

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminalFamilyHomologous superfamily
IPR012178 Replication factor C subunit 1FamilyFamily
IPR013725 DNA replication factor RFC1, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614575 OMIMCerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS)An autosomal recessive neurologic disease characterized by imbalance, cerebellar ataxia, impaired vestibular function, and non-length-dependent sensory deficit. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by intronic AAGGG repeat expansions in intron 2.

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
RFC1_HUMANRFC4_HUMANBioGRID, IntAct18245774 22939629 26344197 28514442 9092549 9488738 details
RFC1_HUMANRFC3_HUMANBioGRID, HPRD, IntAct18245774 22939629 26344197 8692848 9488738 details
RFC1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
RFC1_HUMANPCNA_HUMANBioGRID, HPRD, IntAct10353443 12045192 12171929 12192049 12400013 15225546 22939629 24958773 26344197 26496610 30301766 8861969 8999859 9092549 9649448 details
RFC1_HUMANSSBP3_HUMANBioGRID, IntAct20211142 details
RFC1_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
RFC1_HUMANHDAC1_HUMANBioGRID, HPRD12045192 details
RFC1_HUMANBRD4_HUMANBioGRID, HPRD12192049 31239290 32416067 details
RFC1_HUMANTF65_HUMANBioGRID, HPRD12509469 details
RFC1_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
RFC1_HUMAN1433T_HUMANBioGRID15161933 details
RFC1_HUMANUBC_HUMANBioGRID28190767 details
RFC1_HUMANRFC2_HUMANBioGRID, HPRD, IntAct, UniProt15655353 18245774 22939629 26344197 9488738 details
RFC1_HUMANSMC1A_HUMANBioGRID, HPRD, IntAct16438930 26344197 details
RFC1_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
RFC1_HUMANRFC5_HUMANBioGRID, IntAct18245774 22939629 26344197 28514442 9488738 details
RFC1_HUMANATM_HUMANBioGRID10783165 details
RFC1_HUMANBLM_HUMANBioGRID10783165 details
RFC1_HUMANBRCA1_HUMANBioGRID, HPRD10783165 25184681 details
RFC1_HUMANMLH1_HUMANBioGRID10783165 details
RFC1_HUMANMRE11_HUMANBioGRID10783165 details
RFC1_HUMANMSH2_HUMANBioGRID10783165 details
RFC1_HUMANMSH6_HUMANBioGRID10783165 details
RFC1_HUMANNBN_HUMANBioGRID10783165 details
RFC1_HUMANRAD50_HUMANBioGRID10783165 details
RFC1_HUMANP53_HUMANBioGRID12509469 details
RFC1_HUMANCDK4_HUMANBioGRID, HPRD10353443 details
RFC1_HUMANCCND1_HUMANBioGRID, HPRD10353443 21654808 details
RFC1_HUMANRB_HUMANBioGRID10353443 details
RFC1_HUMANXRCC5_HUMANBioGRID12393188 26344197 details
RFC1_HUMANRAD17_HUMANBioGRID12400013 18245774 details
RFC1_HUMANCTF18_HUMANBioGRID18245774 details
RFC1_HUMANPMS1_HUMANBioGRID17148452 details
RFC1_HUMANRFA1_HUMANBioGRID24332808 26474068 details
RFC1_HUMANSPRTN_HUMANBioGRID23254330 details
RFC1_HUMANATRX_HUMANBioGRID29937341 details
RFC1_HUMANTRI29_HUMANBioGRID26095369 details
RFC1_HUMANSOX2_HUMANBioGRID21280222 details
RFC1_HUMANRFC1_HUMANHPRD12192049 details
RFC1_HUMANCEBPA_HUMANHPRD12509469 details
RFC1_HUMANTCAL1_HUMANHPRD10353443 details
RFC1_HUMANCASP3_HUMANHPRD9235961 9351817 details