Entity Details

Primary name PCKGC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35558
EntryNamePCKGC_HUMAN
FullNamePhosphoenolpyruvate carboxykinase, cytosolic [GTP]
TaxID9606
Evidenceevidence at protein level
Length622
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPCK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006107 oxaloacetate metabolic process
GO:0007568 aging
GO:0014823 response to activity
GO:0018105 peptidyl-serine phosphorylation
GO:0019003 GDP binding
GO:0019543 propionate catabolic process
GO:0030145 manganese ion binding
GO:0030522 intracellular receptor signaling pathway
GO:0031406 carboxylic acid binding
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033993 response to lipid
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0043382 positive regulation of memory T cell differentiation
GO:0046327 glycerol biosynthetic process from pyruvate
GO:0046890 regulation of lipid biosynthetic process
GO:0051365 cellular response to potassium ion starvation
GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
GO:0070062 extracellular exosome
GO:0070365 hepatocyte differentiation
GO:0070741 response to interleukin-6
GO:0071300 cellular response to retinoic acid
GO:0071320 cellular response to cAMP
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071377 cellular response to glucagon stimulus
GO:0071456 cellular response to hypoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0106264 protein serine kinase activity (using GTP as donor)
GO:1904640 response to methionine

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilisingFamilyFamily
IPR008210 Phosphoenolpyruvate carboxykinase, N-terminalFamilyHomologous superfamily
IPR013035 Phosphoenolpyruvate carboxykinase, C-terminalFamilyHomologous superfamily
IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved siteSiteConserved site
IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domainDomainDomain
IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
261680 OMIMPhosphoenolpyruvate carboxykinase deficiency, cytosolic (PCKDC)An autosomal recessive metabolic disorder characterized by impaired gluconeogenesis, hypoglycemia, hypotonia, hepatomegaly, hepatic dysfunction, failure to thrive, lactic acidosis, and elevated tricarboxylic acid intermediates, particularly fumarate, in urine. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00787 AcyclovirDrugbanksmall molecule
DB01819 PhosphoenolpyruvateDrugbanksmall molecule
DB02008 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineDrugbanksmall molecule
DB03267 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineDrugbanksmall molecule
DB03725 5'-GuanylylmethylenebisphosphonateDrugbanksmall molecule
DB09338 MersalylDrugbanksmall molecule